Macrodantin and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrodantin (nitrofurantoin, macrocrystalline) and Actos (pioglitazone hydrochloride). Common drug interactions include retinal detachment among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Macrodantin and Actos. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 11, 2026

38 people who take Macrodantin and Actos together, and have interactions are studied.

Macrodantin and Actos drug interactions.

What are the common drug interactions of Macrodantin and Actos, by gender? *:

female:

Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Thinking abnormal
Thyroid neoplasm (tumour of thyroid)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Tricuspid valve incompetence (inefficient heart valve)
Ulcer
Weight fluctuation
Abdominal pain upper
Cardiac failure congestive
Asthenia (weakness)

male:

Acute respiratory failure
Coma (state of unconsciousness lasting more than six hours)
Thrombocytosis
Urinary tract obstruction
Abdominal pain upper
Diarrhoea
Diverticulum intestinal haemorrhagic (a pouch that is attached to the first part of the small intestine with bleeding)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Rectal haemorrhage (bleeding from anus)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Macrodantin and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiac failure congestive
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Abdominal pain
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Anxiety
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Arthralgia (joint pain)
Asthma
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)

50-59:

Anxiety
Asthenia (weakness)
Back pain
Blindness unilateral
Cataract (clouding of the lens inside the eye)
Chest pain
Coma (state of unconsciousness lasting more than six hours)
Corneal abrasion (loss of the surface of cornea)
Culture urine positive
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

60+:

Anxiety
Cardiac failure congestive
Blood glucose decreased
Cataract (clouding of the lens inside the eye)
Cough
Culture urine positive
Dizziness
Escherichia infection (bacterial infection by escherichia coli)
Eye irritation
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Type 2 Diabetes: 9 people, 23.68%
Pain: 4 people, 10.53%
High Blood Pressure: 4 people, 10.53%
Depression: 4 people, 10.53%
High Blood Cholesterol: 3 people, 7.89%
Stress And Anxiety: 2 people, 5.26%
Neuralgia (pain in one or more nerves): 2 people, 5.26%
Lipidosis (disorder of lipid metabolism involving abnormal accumulation of lipids in the reticuloendothelial cells): 2 people, 5.26%
Bladder Cancer: 2 people, 5.26%
Asthma: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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