Macrodantin and Cozaar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrodantin (nitrofurantoin, macrocrystalline) and Cozaar (losartan potassium). Common drug interactions include erythema of eyelid among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Macrodantin and Cozaar. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Cozaar?

Cozaar has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 45,124 Cozaar users. Check the latest studies of Cozaar.

On Jul, 28, 2026

80 people who take Macrodantin and Cozaar together, and have interactions are studied.

Macrodantin and Cozaar drug interactions.

What are the common drug interactions of Macrodantin and Cozaar, by gender? *:

female:

Erythema of eyelid (redness of the eyelid)
Eye injury
Eye irritation
Eye pain
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Eyelid ptosis (falling of the upper or lower eyelid)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Hallucination, visual (seeing things that aren't there)
Hemiparesis (weakness on one side of the body)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)

male:

Renal failure acute (rapid kidney dysfunction)
Blood creatinine increased
Acute respiratory failure
Back pain
Dizziness
Hypotonia (low muscle tone)
Lethargy (tiredness)
Multi-organ failure (multisystem organ failure)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Oedema (fluid collection in tissue)

What are the common drug interactions of Macrodantin and Cozaar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood creatinine increased
Blood parathyroid hormone increased
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Renal failure acute (rapid kidney dysfunction)
Transplant rejection (a transplant material is not worked)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Back pain
Oedema (fluid collection in tissue)
Renal disorder (kidney disease)

40-49:

Confusional state
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure acute (rapid kidney dysfunction)
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal pain
Abdominal pain upper
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Anxiety
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Arthralgia (joint pain)

50-59:

Anxiety
Asthenia (weakness)
Blindness unilateral
Cardiac failure congestive
Cataract (clouding of the lens inside the eye)
Corneal abrasion (loss of the surface of cornea)
Cough
Culture urine positive
Dehydration (dryness resulting from the removal of water)
Dry eye (lack of adequate tears)

60+:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Chest pain
Coronary artery bypass
Depression
Dyspepsia (indigestion)
Hallucination, visual (seeing things that aren't there)
Infection
Oedema peripheral (superficial swelling)

What are the existing conditions these people have? *

Indigestion: 11 people, 13.75%
Pain: 9 people, 11.25%
High Blood Cholesterol: 9 people, 11.25%
Glaucoma (increased fluid pressure in the eye with vision loss): 7 people, 8.75%
Nausea (feeling of having an urge to vomit): 5 people, 6.25%
Cardiac Disorder: 5 people, 6.25%
Hypoglycemia (low blood sugar): 4 people, 5.00%
Back Pain: 4 people, 5.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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