Macrodantin and Estrace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrodantin (nitrofurantoin, macrocrystalline) and Estrace (estradiol). Common drug interactions include diarrhoea among females.

The phase IV clinical study analyzes what interactions people have when they take Macrodantin and Estrace. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 16,703 Estrace users. Check the latest studies of Estrace.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

72 people who take Macrodantin and Estrace together, and have interactions are studied.

Macrodantin and Estrace drug interactions.

What are the common drug interactions of Macrodantin and Estrace, by gender? *:

female:

Diarrhoea
Hypersensitivity
Abdominal pain
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Asthenia (weakness)
Blood creatinine increased
Blood pressure increased
Faeces hard
Foot fracture
Glomerular filtration rate decreased

male:

n/a

What are the common drug interactions of Macrodantin and Estrace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

International normalised ratio increased
Steatorrhoea (presence of excess fat in faeces)
Alopecia (absence of hair from areas of the body)
Blood potassium decreased
Diarrhoea
Myalgia (muscle pain)
Pancreatitis acute (sudden inflammation of pancreas)
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Flushing (the warm, red condition of human skin)
Herpes zoster
Hypersensitivity
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Influenza
Injection site erythema (redness at injection site)
Injection site haemorrhage (bleeding from injection site)
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Injection site pain
Injection site pruritus (severe itching at injection site)

60+:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Platelet count decreased
Pruritus (severe itching of the skin)
Appetite disorder (abnormal eating habits)
Back pain
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Chronic kidney disease
Constipation
Decreased activity

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 16.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 12.50%
High Blood Pressure: 8 people, 11.11%
Stress And Anxiety: 5 people, 6.94%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 6.94%
Pain: 5 people, 6.94%
Nausea (feeling of having an urge to vomit): 4 people, 5.56%
High Blood Cholesterol: 4 people, 5.56%
Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 4 people, 5.56%
Depression: 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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