Macrodantin and Lanoxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrodantin (nitrofurantoin, macrocrystalline) and Lanoxin (digoxin). Common drug interactions include cough among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Macrodantin and Lanoxin. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Lanoxin?

Lanoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 21,852 Lanoxin users. Check the latest studies of Lanoxin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 04, 2026

33 people who take Macrodantin and Lanoxin together, and have interactions are studied.

Macrodantin and Lanoxin drug interactions.

What are the common drug interactions of Macrodantin and Lanoxin, by gender? *:

female:

Cough
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness postural
Drug ineffective
Drug maladministration
Dry mouth
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Emotional distress
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)

male:

Dyspnoea (difficult or laboured respiration)
Arrhythmia (irregular heartbeat)
Swelling
Collapse of lung (functional breakdown of lung)
Hospitalisation
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Lung neoplasm malignant (cancer tumour of lung)
Blood glucose increased
Blood pressure increased
Bronchiolitis (inflammation of the membranes lining the bronchioles in lungs)

What are the common drug interactions of Macrodantin and Lanoxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diarrhoea
Pharyngolaryngeal pain
Cardiac death
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chest tightness
Lymphadenopathy (disease or enlargement of lymph nodes)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Anaemia (lack of blood)
Arrhythmia (irregular heartbeat)
Fatigue (feeling of tiredness)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

50-59:

n/a

60+:

Dyspnoea (difficult or laboured respiration)
Drug hypersensitivity
Pruritus (severe itching of the skin)
Rash
Cardiac disorder
Nausea (feeling of having an urge to vomit)
Pneumonia
Abdominal pain
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Aspergillosis (an infection caused by a fungus called aspergillus)

What are the existing conditions these people have? *

Dyspnea (difficult or laboured breathing): 5 people, 15.15%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 4 people, 12.12%
Gastric Disorder (disease of stomach): 4 people, 12.12%
Asthma: 4 people, 12.12%
Pulmonary Hypertension Primary (increase in blood pressure in the lung artery with no cause): 3 people, 9.09%
Blood Pressure Abnormal: 3 people, 9.09%
Stress And Anxiety: 2 people, 6.06%
Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 2 people, 6.06%
Pain: 2 people, 6.06%
Nausea And Vomiting: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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