Macrodantin and Requip drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrodantin (nitrofurantoin, macrocrystalline) and Requip (ropinirole hydrochloride). Common drug interactions include osteopenia among females and multiple sclerosis among males.

The phase IV clinical study analyzes what interactions people have when they take Macrodantin and Requip. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

On Jul, 07, 2026

68 people who take Macrodantin and Requip together, and have interactions are studied.

Macrodantin and Requip drug interactions.

What are the common drug interactions of Macrodantin and Requip, by gender? *:

female:

Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Osteoporotic fracture (fracture due to weak bone)
Pain in jaw
Pyrexia (fever)
Stent placement
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Swelling face
Syncope (loss of consciousness with an inability to maintain postural tone)
Therapeutic response unexpected

male:

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Heart rate decreased
Hypotension (abnormally low blood pressure)
Hypotonia (low muscle tone)
Loss of consciousness
Multi-organ failure (multisystem organ failure)
Peptic ulcer perforation
Peripheral swelling
Pleural effusion (water on the lungs)

What are the common drug interactions of Macrodantin and Requip, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cholecystitis acute (rapid infection of gallbladder)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)

30-39:

n/a

40-49:

Nephrolithiasis (calculi in the kidneys)
Gastric bypass
Hydronephrosis (water inside the kidney)
Stent placement
Thyroid cancer
Accidental needle stick
Blood potassium decreased
Circadian rhythm sleep disorder (family of sleep disorders affecting, among other things, the timing of sleep)
Gastrointestinal inflammation (inflammation of stomach and intestine)
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)

50-59:

Renal failure acute (rapid kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Septic shock (shock due to blood infection)
Abasia (inability to walk)
Abdominal pain upper
Activities of daily living impaired
Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Adnexa uteri pain
Balance disorder
Confusional state

60+:

Arthralgia (joint pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Skin reaction
Constipation
Nausea (feeling of having an urge to vomit)
Swelling
Chest pain
Diarrhoea
Drug hypersensitivity
Limb discomfort (discomfort in leg)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 20.59%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 9 people, 13.24%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 13.24%
Pain: 6 people, 8.82%
Hereditary Angioedema (recurrent episodes of severe swelling): 5 people, 7.35%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.35%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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