Macugen and Levofloxacin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macugen (pegaptanib sodium) and Levofloxacin (levofloxacin; sodium chloride). Common drug interactions include myocardial infarction among females and cerebral infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Macugen and Levofloxacin. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Macugen?

Macugen has active ingredients of pegaptanib sodium. eHealthMe is studying from 615 Macugen users. Check the latest studies of Macugen.

What is Levofloxacin?

Levofloxacin has active ingredients of levofloxacin; sodium chloride. It is often used in sinusitis. eHealthMe is studying from 16,335 Levofloxacin users. Check the latest studies of Levofloxacin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

39 people who take Macugen and Levofloxacin together, and have interactions are studied.

Macugen and Levofloxacin drug interactions.

What are the common drug interactions of Macugen and Levofloxacin, by gender? *:

female:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Blood pressure decreased
Cardiac failure
Optic ischaemic neuropathy (optic nerve damage due to lack of blood supply)
Retinal haemorrhage (bleeding from retina)
Ventricular hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do)
Chest pain
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Cough
Dyspnoea (difficult or laboured respiration)

male:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Endophthalmitis (inflammation of the internal coats of the eye)
Conjunctivitis allergic (inflammation of the conjunctiva due to allergy)
Eye pruritus (eye itching)
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Drug effect decreased

What are the common drug interactions of Macugen and Levofloxacin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Vitreous haemorrhage (intraocular (inside the eye) bleeding)
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Blood pressure systolic increased
Optic ischaemic neuropathy (optic nerve damage due to lack of blood supply)
Retinal vein occlusion (a blockage of the small veins that carry blood away from the retina)
Ventricular hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do)
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Conjunctivitis allergic (inflammation of the conjunctiva due to allergy)
Eye pruritus (eye itching)

What are the existing conditions these people have? *

Macular Degeneration (painless eye condition that leads to the gradual loss of central vision): 20 people, 51.28%
Age-Related Macular Degeneration: 8 people, 20.51%
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest): 4 people, 10.26%
Polypoidal Choroidal Vasculopathy (polyp-like sub-retinal pigment epithelium vascular abnormalities predominantly found in the macula and peripapillary region): 3 people, 7.69%
Choroidal Neovascularisation (creation of new blood vessels in vascular layer of eye): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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