Magnesium oxide and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Magnesium oxide (magnesium) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include pericardial effusion among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Magnesium oxide and Excedrin. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Magnesium oxide?

Magnesium oxide has active ingredients of magnesium. It is often used in migraine. eHealthMe is studying from 19,022 Magnesium oxide users. Check the latest studies of Magnesium oxide.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

35 people who take Magnesium oxide and Excedrin together, and have interactions are studied.

Magnesium oxide and Excedrin drug interactions.

What are the common drug interactions of Magnesium Oxide and Excedrin, by gender? *:

female:

Pericardial effusion (fluid around the heart)
Pericarditis (inflammation of the pericardium)
Peroneal nerve palsy
Pleuritic pain
Pneumonia
Productive cough
Pruritus (severe itching of the skin)
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary oedema (fluid accumulation in the lungs)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)

male:

Cardiac failure congestive
Blood glucose decreased
Diarrhoea
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Respiratory disorder (respiratory disease)
Urine output decreased
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

What are the common drug interactions of Magnesium Oxide and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Urinary tract infection
Ventricular extrasystoles (premature cardiac contraction)
Abdominal pain upper
Anxiety
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Emotional distress
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

40-49:

Abdominal discomfort
Abdominal pain upper
Cough
Depressed mood
Diarrhoea
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Respiratory disorder (respiratory disease)
Urine output decreased
Arthralgia (joint pain)

50-59:

Cystitis (inflammation of the wall of the bladder)
Herpes simplex (herpes simplex is a common viral infection)
Small intestinal obstruction (blockage in small intestine)
Cardiac failure
Chest pain
Dyspepsia (indigestion)
Emotional distress
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Injury

60+:

Cardiac failure congestive
Blood glucose decreased
Somnolence (a state of near-sleep, a strong desire for sleep)
Thyroid disorder (thyroid diseases)
Weight increased
Abdominal pain
Anger
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)

What are the existing conditions these people have? *

Drowsiness: 10 people, 28.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 28.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 25.71%
Type 2 Diabetes: 6 people, 17.14%
Cardiac Failure: 6 people, 17.14%
Swelling Face: 6 people, 17.14%
Drug Hypersensitivity: 6 people, 17.14%
Pain: 6 people, 17.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 17.14%
Nausea (feeling of having an urge to vomit): 4 people, 11.43%

* Approximation only. Some reports may have incomplete information.

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