Magnesium sulfate and Caffeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Magnesium sulfate (magnesium sulfate) and Caffeine (caffeine). Common drug interactions include neutropenic colitis among females and drug hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Magnesium sulfate and Caffeine. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Magnesium sulfate?

Magnesium sulfate has active ingredients of magnesium sulfate. It is often used in migraine. eHealthMe is studying from 18,024 Magnesium sulfate users. Check the latest studies of Magnesium sulfate.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

38 people who take Magnesium sulfate and Caffeine together, and have interactions are studied.

Magnesium sulfate and Caffeine drug interactions.

What are the common drug interactions of Magnesium Sulfate and Caffeine, by gender? *:

female:

Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)
Pneumonia
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Restlessness (not able to rest)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinusitis (inflammation of sinus)
Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting

male:

Drug hypersensitivity
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Abdominal wall cyst (abnormal membranous sac containing a gaseous, liquid, or semisolid substance on abdominal wall)
Altered state of consciousness (altered state of mind)
Anal abscess
Anal erosion
Anal polyp (abnormal growth sticking out from the mucous membrane lining the anus or colon)
Asthenia (weakness)
Bacteraemia (presence of bacteria in the blood)
Carbuncle (a carbuncle is an abscess larger than a boil)

What are the common drug interactions of Magnesium Sulfate and Caffeine, by age (0-1 to 60+)? *:

0-1:

Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Abdominal distension
Asthenia (weakness)
Dyspnoea (difficult or laboured respiration)
Frequent bowel movements
General physical health deterioration (weak health status)
Hyperthermia (body temperature greatly above normal)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Hypotension (abnormally low blood pressure)

2-9:

n/a

10-19:

n/a

20-29:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Allergic sinusitis
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Disease progression
Leukoencephalopathy (disease of the white matter in the brain)
Lip swelling
Nausea (feeling of having an urge to vomit)
Pneumonia
Septic shock (shock due to blood infection)
Sinusitis (inflammation of sinus)

30-39:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Normal newborn
Maternal exposure during pregnancy (use of substance during pregnancy)
Ketosis (a state of elevated levels of ketone bodies in the body)
Hypertension (high blood pressure)
Hypokalaemia (low potassium)
Ketonuria (ketones in urine)
Anion gap increased
Anxiety

40-49:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Cardiac arrest
Death

50-59:

Drug hypersensitivity
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Haematoma (collection of blood outside the blood vessels)
Haematuria (presence of blood in urine)

60+:

Bacteraemia (presence of bacteria in the blood)
Device failure
Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Small intestinal obstruction (blockage in small intestine)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Abdominal pain
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)

What are the existing conditions these people have? *

Fever: 7 people, 18.42%
Nausea (feeling of having an urge to vomit): 7 people, 18.42%
Mania (a state of abnormally elevated or irritable mood): 6 people, 15.79%
Pain: 5 people, 13.16%
Constipation: 5 people, 13.16%
Bone Marrow Conditioning Regimen: 5 people, 13.16%
Pneumonia: 5 people, 13.16%
Diarrhea: 4 people, 10.53%
Diabetes: 4 people, 10.53%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 4 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Magnesium sulfate and Caffeine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously