Makena and Reglan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Makena (hydroxyprogesterone caproate) and Reglan (metoclopramide hydrochloride). Common drug interactions include premature delivery among females.

The phase IV clinical study analyzes what interactions people have when they take Makena and Reglan. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Makena?

Makena has active ingredients of hydroxyprogesterone caproate. eHealthMe is studying from 24,292 Makena users. Check the latest studies of Makena.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

On Jul, 26, 2026

38 people who take Makena and Reglan together, and have interactions are studied.

What are the common drug interactions of Makena and Reglan, by gender? *:

female:

Premature delivery
Premature labour
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Urinary tract infection
Abdominal pain
Back pain
Cervical incompetence (serious pregnancy complication in which the cervix starts to open)
Cervix haemorrhage uterine (bleeding from cervix in birth canal)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)

male:

n/a

What are the common drug interactions of Makena and Reglan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Premature delivery
Pain
Scab (a hard coating on the skin formed during the wound healing)
Injection site swelling
Abdominal pain
Back pain
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Injection site pain

30-39:

Cervical incompetence (serious pregnancy complication in which the cervix starts to open)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hypersensitivity
Injection site swelling
Injection site urticaria (rash of round, red welts on the skin at injection site)
Labour induction
Oligohydramnios (a condition in pregnancy characterized by a deficiency of amniotic fluid)
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)

40-49:

Premature delivery
Premature labour

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Premature Delivery: 30 people, 78.95%
Nausea (feeling of having an urge to vomit): 18 people, 47.37%
Nausea And Vomiting: 10 people, 26.32%
Birth Control: 9 people, 23.68%
Stress And Anxiety: 3 people, 7.89%
Premature Labor: 3 people, 7.89%
Migraine (headache): 3 people, 7.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.26%
Asthma: 2 people, 5.26%
Anaemia (lack of blood): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Makena and Reglan?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously