Malarone and Elestrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Malarone (atovaquone; proguanil hydrochloride) and Elestrin (estradiol). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Malarone and Elestrin. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Malarone?

Malarone has active ingredients of atovaquone; proguanil hydrochloride. It is often used in malaria. eHealthMe is studying from 3,098 Malarone users. Check the latest studies of Malarone.

What is Elestrin?

Elestrin has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 161 Elestrin users. Check the latest studies of Elestrin.



On Aug, 02, 2026

12 people who take Malarone and Elestrin together, and have interactions are studied.

Malarone and Elestrin drug interactions.

What are the common drug interactions of Malarone and Elestrin, by gender? *:

female:

  1. Fatigue (feeling of tiredness)
  2. Lyme disease (a bacterial infection that is spread to humans by infected ticks)
  3. Malaise (a feeling of general discomfort or uneasiness)
  4. Neuropathy peripheral (surface nerve damage)
  5. Post-traumatic stress disorder
  6. Craniocerebral injury (injury to cranium and brain)
  7. Memory impairment
  8. Visual impairment
  9. Balance disorder
  10. Cat scratch disease (bacterial infection by cat scratch)

male:

n/a

What are the common drug interactions of Malarone and Elestrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 100.00%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 100.00%
  3. Drowsiness: 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Malarone and Elestrin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Malarone and Elestrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Malarone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Elestrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Malarone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Elestrin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on atovaquone; proguanil hydrochloride and estradiol (the active ingredients of Malarone and Elestrin, respectively), and Malarone and Elestrin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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