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Matulane and Lamotrigine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Matulane (procarbazine hydrochloride) and Lamotrigine (lamotrigine). Common drug interactions include nausea among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Matulane and Lamotrigine. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Matulane?

Matulane has active ingredients of procarbazine hydrochloride. eHealthMe is studying from 3,440 Matulane users. Check the latest studies of Matulane.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

32 people who take Matulane and Lamotrigine together, and have interactions are studied.

Matulane and Lamotrigine drug interactions.

What are the common drug interactions of Matulane and Lamotrigine, by gender? *:

female:

  1. Nausea (feeling of having an urge to vomit)
  2. Fatigue (feeling of tiredness)
  3. Headache (pain in head)
  4. Depression
  5. Chills (felling of cold)
  6. Cold sweat
  7. Drug ineffective
  8. Hepatitis (inflammation of the liver)
  9. Hyperhidrosis (abnormally increased sweating)
  10. Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)

male:

  1. Nausea (feeling of having an urge to vomit)
  2. Fatigue (feeling of tiredness)
  3. Rash
  4. White blood cell count decreased
  5. Abdominal discomfort
  6. Burn oesophageal (burn in the oesophagus)
  7. Death
  8. Diarrhoea
  9. Disease progression
  10. Malignant neoplasm progression (cancer tumour came back)

What are the common drug interactions of Matulane and Lamotrigine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. White blood cell count decreased

30-39:

n/a

40-49:

  1. Nausea (feeling of having an urge to vomit)
  2. Burn oesophageal (burn in the oesophagus)
  3. Death
  4. Fatigue (feeling of tiredness)
  5. Oesophageal ulcer (ulcer of oesophagus)
  6. Vomiting

50-59:

  1. Disease progression

60+:

  1. Nausea (feeling of having an urge to vomit)
  2. Peripheral swelling

What are the existing conditions these people have? *

  1. Brain Neoplasm Malignant (brain cancer tumour): 26 people, 81.25%
  2. Brain Neoplasm (tumour of brain): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Matulane and Lamotrigine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Matulane and Lamotrigine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Matulane:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Lamotrigine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Matulane and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lamotrigine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on procarbazine hydrochloride and lamotrigine (the active ingredients of Matulane and Lamotrigine, respectively), and Matulane and Lamotrigine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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