Mavyret and Januvia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mavyret (glecaprevir; pibrentasvir) and Januvia (sitagliptin phosphate). Common drug interactions include angioedema among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Mavyret and Januvia. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Mavyret?

Mavyret has active ingredients of glecaprevir; pibrentasvir. eHealthMe is studying from 10,533 Mavyret users. Check the latest studies of Mavyret.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

On Jul, 04, 2026

17 people who take Mavyret and Januvia together, and have interactions are studied.

What are the common drug interactions of Mavyret and Januvia, by gender? *:

female:

Angioedema (rapid swelling of the dermis)
Abdominal distension
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Fatigue (feeling of tiredness)
Leukaemic lymphoma (a rare cancer of the immune systems own t-cells)
Asthenia (weakness)
Blood glucose decreased
Chest pain
Decreased appetite
Dizziness

male:

Headache (pain in head)
Asthenia (weakness)
Chills (felling of cold)
Dysplasia (enlargement of an organ or tissue)
Gallbladder operation
Gastric ulcer (stomach ulcer)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrointestinal inflammation (inflammation of stomach and intestine)
General physical health deterioration (weak health status)
Influenza like illness

What are the common drug interactions of Mavyret and Januvia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Abdominal distension
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Fatigue (feeling of tiredness)
Leukaemic lymphoma (a rare cancer of the immune systems own t-cells)
Asthenia (weakness)
Chills (felling of cold)
Gastric ulcer (stomach ulcer)
Gastrointestinal inflammation (inflammation of stomach and intestine)
Influenza like illness
Oesophageal stenosis (narrowing of oesophagus)

60+:

Angioedema (rapid swelling of the dermis)
Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
Fall
Gallbladder operation
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
General physical health deterioration (weak health status)
Hip fracture
Hospitalisation
Intestinal ulcer
Large intestinal ulcer

What are the existing conditions these people have? *

Hepatitis C: 9 people, 52.94%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 5.88%
Neuritis (inflammation of nerve): 1 person, 5.88%
Muscle Aches (muscle pain): 1 person, 5.88%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.88%
Insomnia (sleeplessness): 1 person, 5.88%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.88%
High Blood Pressure: 1 person, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.88%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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