Maxalt-mlt and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxalt-mlt (rizatriptan benzoate) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include multiple sclerosis relapse among females and eye irritation among males.

The phase IV clinical study analyzes what interactions people have when they take Maxalt-mlt and Vicodin. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Maxalt-mlt?

Maxalt-mlt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 1,534 Maxalt-mlt users. Check the latest studies of Maxalt-mlt.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

On Jul, 28, 2026

26 people who take Maxalt-mlt and Vicodin together, and have interactions are studied.

Maxalt-mlt and Vicodin drug interactions.

What are the common drug interactions of Maxalt-Mlt and Vicodin, by gender? *:

female:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Fall
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Urinary tract infection
Bladder dysfunction
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Respiratory failure (inadequate gas exchange by the respiratory system)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Insomnia (sleeplessness)
Sinusitis (inflammation of sinus)

male:

Eye irritation
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Urinary tract infection
Eye disorder
Bladder dysfunction
Fall
Hyperbilirubinaemia (excess of bilirubin in the blood)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)

What are the common drug interactions of Maxalt-Mlt and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary infarction (death of a small area of lung)
Blood cholesterol increased
Blood triglycerides increased
Depression
Type 2 diabetes mellitus

20-29:

n/a

30-39:

Eye irritation
Dry eye (lack of adequate tears)
Insomnia (sleeplessness)
Irritable bowel syndrome
Muscle twitching
Psychomotor hyperactivity (feelings of extreme restlessness)
Sinus disorder (disease of sinus)
Sinusitis (inflammation of sinus)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Eye disorder

40-49:

Abdominal pain
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Chest pain
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Diarrhoea haemorrhagic (bloody diarrhoea)
Dysphoria (generalized dissatisfaction with life)
Dyspnoea (difficult or laboured respiration)
Mesenteric occlusion (blockage in mesenteric artery)

50-59:

Fall
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Urinary tract infection
Bladder dysfunction
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Respiratory failure (inadequate gas exchange by the respiratory system)
Opportunistic infection (a microorganism that normally does not cause disease but becomes pathogenic when the body's immune system is impaired and unable to fight)
Aggression
Dehydration (dryness resulting from the removal of water)

60+:

Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Bladder dysfunction
Drug ineffective
Headache (pain in head)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neck pain
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Fall
Hyperbilirubinaemia (excess of bilirubin in the blood)

What are the existing conditions these people have? *

Sleep Disorder: 9 people, 34.62%
Depression: 9 people, 34.62%
Stress And Anxiety: 9 people, 34.62%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 34.62%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 34.62%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 8 people, 30.77%
Restless Leg Syndrome (a powerful urge to move your legs): 8 people, 30.77%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 8 people, 30.77%
Cystitis Interstitial (unknown cause characterized by bladder pain): 8 people, 30.77%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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