Maxalt and Fiorinal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxalt (rizatriptan benzoate) and Fiorinal (aspirin; butalbital; caffeine). Common drug interactions include oesophageal spasm among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Maxalt and Fiorinal. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Maxalt?

Maxalt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 12,754 Maxalt users. Check the latest studies of Maxalt.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

On Jul, 08, 2026

75 people who take Maxalt and Fiorinal together, and have interactions are studied.

What are the common drug interactions of Maxalt and Fiorinal, by gender? *:

female:

Oesophageal spasm (contraction of oesophagus)
Suicidal ideation
Surgery
Therapeutic response decreased (less preventive response)
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal distension
Femur fracture
Forearm fracture (fracture in between wrist to elbow)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Lower limb fracture

male:

Dizziness
Drug addiction
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Influenza
Lethargy (tiredness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sinusitis (inflammation of sinus)
Throat irritation

What are the common drug interactions of Maxalt and Fiorinal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anuria (failure of the kidneys to produce urine)
Attention deficit/hyperactivity disorder
Blood cholesterol increased
Burning sensation
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Depression

30-39:

Depression
Fall
Femur fracture
Forearm fracture (fracture in between wrist to elbow)
Gastric ulcer (stomach ulcer)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Lower limb fracture
Oesophageal spasm (contraction of oesophagus)

40-49:

Pain
Drug hypersensitivity
Drug ineffective
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Blood thyroid stimulating hormone increased
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Constipation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

50-59:

Dysphonia (speech disorder attributable to a disorder of phonation)
Facial pain
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Foot deformity (functional disability of foot)
Granulocyte count decreased
Hypoaesthesia (reduced sense of touch or sensation)
Impaired work ability
Inflammation
Influenza

60+:

Depression
Femur fracture
Upper limb fracture
Urinary tract infection
Wrist fracture
Blood pressure decreased
Cataract (clouding of the lens inside the eye)
Drug ineffective
Heart rate decreased
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 17.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 16.00%
High Blood Pressure: 11 people, 14.67%
Insomnia (sleeplessness): 9 people, 12.00%
Osteoporosis (bones weak and more likely to break): 9 people, 12.00%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 7 people, 9.33%
Headache (pain in head): 7 people, 9.33%
Urinary Tract Infection: 7 people, 9.33%
Gastrointestinal Motility Disorder (abnormal intestinal contractions): 6 people, 8.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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