Maxalt and Nucynta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxalt (rizatriptan benzoate) and Nucynta (tapentadol hydrochloride). Common drug interactions include postural orthostatic tachycardia syndrome among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Maxalt and Nucynta. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Maxalt?

Maxalt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 12,754 Maxalt users. Check the latest studies of Maxalt.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

On Aug, 06, 2026

85 people who take Maxalt and Nucynta together, and have interactions are studied.

What are the common drug interactions of Maxalt and Nucynta, by gender? *:

female:

Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Pyelonephritis (inflammation of kidney caused by bacteria)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Renal pain (kidney pain)
Respiratory rate decreased (less breathing rate/min)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin exfoliation (removal of the oldest dead skin cells)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)

male:

Drug ineffective
Constipation
Fatigue (feeling of tiredness)
Glycosylated haemoglobin increased
Grip strength decreased
Joint swelling
Mood altered (changes in mood)
Muscular weakness (muscle weakness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Poor quality sleep

What are the common drug interactions of Maxalt and Nucynta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hypertension (high blood pressure)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Insomnia (sleeplessness)
Pain in extremity
Renal pain (kidney pain)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Ovarian cyst (fluid filled sac of the ovary)

30-39:

Constipation
Nausea (feeling of having an urge to vomit)
Arthralgia (joint pain)
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Emotional distress
Glycosylated haemoglobin increased
Grip strength decreased
Joint swelling
Mood altered (changes in mood)

40-49:

Thrombosis (formation of a blood clot inside a blood vessel)
Vertigo
Vitamin d deficiency
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood pressure increased
Blood sodium decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

50-59:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Blood pressure increased
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry mouth
Fatigue (feeling of tiredness)
Heart rate increased
Influenza like illness

60+:

Acute respiratory failure
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Headache (pain in head)
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Respiration (transport of oxygen from the outside air to the cells within tissues)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Unresponsive to stimuli
Diarrhoea

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 42 people, 49.41%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 26 people, 30.59%
Nausea (feeling of having an urge to vomit): 10 people, 11.76%
Muscle Spasms (muscle contraction): 8 people, 9.41%
Depression: 7 people, 8.24%
Neuralgia (pain in one or more nerves): 6 people, 7.06%
Headache (pain in head): 6 people, 7.06%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 7.06%
Stress And Anxiety: 5 people, 5.88%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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