Maxzide and Advil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxzide (hydrochlorothiazide; triamterene) and Advil (ibuprofen). Common drug interactions include pathological fracture among females and activities of daily living impaired among males.

The phase IV clinical study analyzes what interactions people have when they take Maxzide and Advil. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Maxzide?

Maxzide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 9,152 Maxzide users. Check the latest studies of Maxzide.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

On Jul, 22, 2026

86 people who take Maxzide and Advil together, and have interactions are studied.

What are the common drug interactions of Maxzide and Advil, by gender? *:

female:

Pathological fracture (broken bone caused by disease)
Pyelocaliectasis
Swelling face
Tooth loss
Weight increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dysuria (painful or difficult urination)
Joint injury
Joint swelling
Knee arthroplasty

male:

Activities of daily living impaired
Cardiac failure congestive
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Constipation
Electrocardiogram st segment depression
Fatigue (feeling of tiredness)
Furuncle (infection of the hair follicle)
Injury
Intervertebral disc protrusion (spinal disc protrusion)

What are the common drug interactions of Maxzide and Advil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pulmonary embolism (blockage of the main artery of the lung)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gait disturbance
Muscle spasms (muscle contraction)
Pain in extremity
Activities of daily living impaired
Alpha haemolytic streptococcal infection (infections with alpha-haemolytic strep bacteria are common; many strains live naturally in humans)
Anxiety
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)

40-49:

Drug hypersensitivity
Anxiety
Chest pain
Diarrhoea
Electrolyte imbalance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Joint effusion (presence of extra fluid in joint covering)
Muscle atrophy (a decrease in the mass of the muscle)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)

50-59:

Affect lability (emotional incontinence)
Anaemia (lack of blood)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety
Bone pain
Cardiac disorder
Chest pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depression
Disturbance in attention

60+:

Back pain
Nausea (feeling of having an urge to vomit)
Hot flush (sudden feelings of heat)
Joint crepitation
Joint range of motion decreased (disease of joint movement)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Spinal fusion surgery
Ulcer

What are the existing conditions these people have? *

Constipation: 13 people, 15.12%
Muscle Spasms (muscle contraction): 12 people, 13.95%
Metastases To Bone (cancer spreads to bone): 11 people, 12.79%
Breast Cancer Metastatic: 11 people, 12.79%
Breast Cancer: 11 people, 12.79%
Osteoporosis (bones weak and more likely to break): 6 people, 6.98%
Multiple Myeloma (cancer of the plasma cells): 6 people, 6.98%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 6.98%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 5.81%
High Blood Cholesterol: 5 people, 5.81%

* Approximation only. Some reports may have incomplete information.

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