Maxzide and Benzonatate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxzide (hydrochlorothiazide; triamterene) and Benzonatate (benzonatate). Common drug interactions include haemoglobin decreased among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Maxzide and Benzonatate. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Maxzide?

Maxzide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 9,152 Maxzide users. Check the latest studies of Maxzide.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

On Jul, 15, 2026

48 people who take Maxzide and Benzonatate together, and have interactions are studied.

Maxzide and Benzonatate drug interactions.

What are the common drug interactions of Maxzide and Benzonatate, by gender? *:

female:

Haemoglobin decreased
Heart rate increased
Injury
Intervertebral disc protrusion (spinal disc protrusion)
Left ventricular dysfunction
Lung neoplasm malignant (cancer tumour of lung)
Myalgia (muscle pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Nephrolithiasis (calculi in the kidneys)

male:

Pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Epididymitis (pain in the scrotum or testicle)
Necrosis (the death of body tissue)
Nerve injury
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pneumonia
Prostate cancer
Scar

What are the common drug interactions of Maxzide and Benzonatate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Bone density decreased
Emotional distress
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Vitamin d deficiency
Spinal fracture (fracture in one of vertebrae)

40-49:

Abscess limb (limb infection)
Balanoposthitis (inflammation of the glands penis and the foreskin)
Cellulitis (infection under the skin)
Epididymitis (pain in the scrotum or testicle)
Necrosis (the death of body tissue)
Nerve injury
Pain
Prostate cancer
Scar
Scrotal abscess (pus in scrotum)

50-59:

Myocardial strain
Oxygen saturation decreased
Pain
Ph body fluid
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Respiratory distress (difficulty in breathing)
Respiratory failure (inadequate gas exchange by the respiratory system)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

60+:

Pneumonia
Nausea (feeling of having an urge to vomit)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Atelectasis (partial or complete collapse of the lung)
Diarrhoea
Dizziness
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hypoxia (low oxygen in tissues)
Iron deficiency anaemia
Oedema peripheral (superficial swelling)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 16.67%
Depression: 6 people, 12.50%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 10.42%
Type 2 Diabetes: 3 people, 6.25%
Stress And Anxiety: 3 people, 6.25%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 6.25%
Migraine (headache): 3 people, 6.25%
High Blood Cholesterol: 3 people, 6.25%
Diabetes: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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