Maxzide and Lodine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxzide (hydrochlorothiazide; triamterene) and Lodine (etodolac). Common drug interactions include cervical spinal stenosis among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Maxzide and Lodine. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Maxzide?

Maxzide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 9,152 Maxzide users. Check the latest studies of Maxzide.

What is Lodine?

Lodine has active ingredients of etodolac. It is often used in pain. eHealthMe is studying from 3,846 Lodine users. Check the latest studies of Lodine.

On Jul, 11, 2026

28 people who take Maxzide and Lodine together, and have interactions are studied.

What are the common drug interactions of Maxzide and Lodine, by gender? *:

female:

Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Hand fracture
Injection site erythema (redness at injection site)
Injection site pruritus (severe itching at injection site)
Injection site reaction
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Joint dislocation (a joint position is changed from normal position)
Lumbar radiculopathy (radicular pain in the low back and legs)
Nasopharyngitis (inflammation of the nasopharynx)

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Maxzide and Lodine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood cholesterol increased
Dehydration (dryness resulting from the removal of water)
Obesity (having too much body fat)
Suicidal ideation
Type 2 diabetes mellitus
Weight increased

30-39:

n/a

40-49:

Alopecia (absence of hair from areas of the body)
Bone disorder
Bone formation decreased
Bone neoplasm (tumour of bone)
Bone pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Hand fracture
Injection site erythema (redness at injection site)

50-59:

Dry mouth
Cardiovascular disorder (heart diseases)
Keratoconjunctivitis (inflammation of the cornea and conjunctiva)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fall
Knee arthroplasty
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oedema (fluid collection in tissue)
Salivary gland enlargement (increased size of salivary gland)

60+:

Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Nausea (feeling of having an urge to vomit)
Face oedema (swelling of face)
Hypersensitivity
Incontinence (lack of moderation or self-control)
Injection site haemorrhage (bleeding from injection site)
Mitral valve incompetence (inefficient heart valve)
Muscle cramps (painful sensations caused by muscle contraction)
Oedema peripheral (superficial swelling)
Palpitations (feelings or sensations that your heart is pounding or racing)

What are the existing conditions these people have? *

Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 14.29%
Stress And Anxiety: 3 people, 10.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.71%
Back Pain: 3 people, 10.71%
Depression: 3 people, 10.71%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 10.71%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 10.71%
Pulmonary Congestion (congestion in the lungs): 2 people, 7.14%
Orgasmic Dysfunction (not getting orgasm): 2 people, 7.14%
Muscle Spasms (muscle contraction): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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