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Maxzide and Lotronex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Maxzide (hydrochlorothiazide; triamterene) and Lotronex (alosetron hydrochloride). Common drug interactions include colitis ischaemic among females.

The phase IV clinical study analyzes what interactions people have when they take Maxzide and Lotronex. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Maxzide?

Maxzide has active ingredients of hydrochlorothiazide; triamterene. It is often used in high blood pressure. eHealthMe is studying from 9,152 Maxzide users. Check the latest studies of Maxzide.

What is Lotronex?

Lotronex has active ingredients of alosetron hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 6,841 Lotronex users. Check the latest studies of Lotronex.

On Jul, 06, 2026

16 people who take Maxzide and Lotronex together, and have interactions are studied.

Maxzide and Lotronex drug interactions.

What are the common drug interactions of Maxzide and Lotronex, by gender? *:

female:

  1. Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
  2. Diarrhoea
  3. Pain
  4. Pleural effusion (water on the lungs)
  5. Anaemia (lack of blood)
  6. Blood alkaline phosphatase increased
  7. Blood calcium increased
  8. Blood in stool
  9. Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
  10. Faecal impaction

male:

n/a

What are the common drug interactions of Maxzide and Lotronex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Abdominal pain lower
  2. Constipation

50-59:

  1. Dehydration (dryness resulting from the removal of water)
  2. Blood in stool
  3. Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
  4. Diarrhoea
  5. Drug ineffective
  6. Faecal impaction
  7. Stress incontinence (leak urine with things like coughing, sneezing or exercise)
  8. Vomiting
  9. Abdominal pain
  10. Abdominal pain lower

60+:

  1. Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
  2. Sepsis (a severe blood infection that can lead to organ failure and death)
  3. Diarrhoea
  4. Haemorrhoids (a swollen vein or group of veins in the region of the anus)
  5. Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
  6. Pain
  7. Protein total increased
  8. Abdominal adhesions (inflammation of abdomen)
  9. Abdominal pain lower
  10. Abdominal tenderness

* Approximation only. Some reports may have incomplete information.

Do you take Maxzide and Lotronex?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Maxzide and Lotronex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Maxzide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Lotronex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Maxzide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lotronex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; triamterene and alosetron hydrochloride (the active ingredients of Maxzide and Lotronex, respectively), and Maxzide and Lotronex (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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