Medrol and Roxicet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Medrol (methylprednisolone) and Roxicet (acetaminophen; oxycodone hydrochloride). Common drug interactions include cardioactive drug level increased among females and thrombocytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Medrol and Roxicet. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Medrol?

Medrol has active ingredients of methylprednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,443 Medrol users. Check the latest studies of Medrol.

What is Roxicet?

Roxicet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 2,254 Roxicet users. Check the latest studies of Roxicet.

On Jul, 12, 2026

30 people who take Medrol and Roxicet together, and have interactions are studied.

What are the common drug interactions of Medrol and Roxicet, by gender? *:

female:

Cardioactive drug level increased
Chronic kidney disease
Cough
Delirium (wild excitement)
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspepsia (indigestion)
Electrocardiogram qt prolonged
Emotional distress
Encephalopathy (functioning of the brain is affected by some agent or condition)

male:

Thrombocytopenia (decrease of platelets in blood)
Confusional state
Blood cholesterol increased
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Erectile dysfunction
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Injury
Intervertebral disc degeneration (spinal disc degeneration)
Spinal osteoarthritis (joint cartilage loss in spine)

What are the common drug interactions of Medrol and Roxicet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Nausea (feeling of having an urge to vomit)
Confusional state
Depression
Drug dependence
Insomnia (sleeplessness)
Pain in extremity
Diarrhoea
Dizziness
Drug addiction
Drug tolerance increased

50-59:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block first degree (heart block first degree)
Back pain
Blood uric acid increased
Bradycardia (abnormally slow heart action)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Cardiac arrest
Cardiac death
Cardioactive drug level increased
Cough

60+:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone disorder
Cartilage injury
Cerebral artery stenosis (hardening of brain blood vessels)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Chest pain
Confusional state
Depression
Diarrhoea

What are the existing conditions these people have? *

Prostate Cancer: 9 people, 30.00%
Bone Density Abnormal: 9 people, 30.00%
Cardiac Disorder: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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