Medroxyprogesterone acetate and Mirena drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Medroxyprogesterone acetate (medroxyprogesterone acetate) and Mirena (levonorgestrel). Common drug interactions include uterine perforation among females.

The phase IV clinical study analyzes what interactions people have when they take Medroxyprogesterone acetate and Mirena. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Medroxyprogesterone acetate?

Medroxyprogesterone acetate has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 12,600 Medroxyprogesterone acetate users. Check the latest studies of Medroxyprogesterone acetate.

What is Mirena?

Mirena has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 145,266 Mirena users. Check the latest studies of Mirena.

On Jul, 29, 2026

24 people who take Medroxyprogesterone acetate and Mirena together, and have interactions are studied.

Medroxyprogesterone acetate and Mirena drug interactions.

What are the common drug interactions of Medroxyprogesterone Acetate and Mirena, by gender? *:

female:

Uterine perforation (accidental puncture of the uterus)
Device dislocation
Anxiety
Pain
Dizziness
Haemoglobin decreased
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Menstrual disorder (disease of menstrual cycle)
Pallor
Post procedural haemorrhage (post procedural bleeding)

male:

n/a

What are the common drug interactions of Medroxyprogesterone Acetate and Mirena, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anxiety
Depression
Uterine perforation (accidental puncture of the uterus)

20-29:

Device dislocation
Femoral neck fracture (neck of femur bone fracture)
Procedural pain
Abdominal pain
Dizziness
Haemoglobin decreased
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Menstrual disorder (disease of menstrual cycle)
Pallor
Post procedural haemorrhage (post procedural bleeding)

30-39:

Abdominal pain lower
Dysmenorrhoea (painful menstruation)
Dyspareunia (painful sexual intercourse)
Pelvic pain
Pregnancy with contraceptive device
Urinary tract infection
Vaginal discharge
Varicose vein (veins that have become enlarged and tortuous)
Abortion spontaneous (naturally occurring miscarriage)
Vaginal haemorrhage (vaginal bleeding)

40-49:

Device dislocation
Genital haemorrhage (bleeding from genital)
Infection
Medical device pain (pain due to medical device)
Pelvic adhesions
Pelvic pain
Uterine injury
Depression
Injury
Uterine perforation (accidental puncture of the uterus)

50-59:

Iron deficiency anaemia
Uterine haemorrhage (uterine bleeding)

60+:

n/a

What are the existing conditions these people have? *

Heavy Or Prolong Menstrual Bleeding: 4 people, 16.67%
Abdominal Pain: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Medroxyprogesterone acetate and Mirena?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously