Mefenamic acid and Letairis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mefenamic acid (mefenamic acid) and Letairis (ambrisentan). Common drug interactions include headache among females.

The phase IV clinical study analyzes what interactions people have when they take Mefenamic acid and Letairis. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Mefenamic acid?

Mefenamic acid has active ingredients of mefenamic acid. It is often used in painful menstrual periods. eHealthMe is studying from 4,844 Mefenamic acid users. Check the latest studies of Mefenamic acid.

What is Letairis?

Letairis has active ingredients of ambrisentan. It is often used in pulmonary hypertension. eHealthMe is studying from 94,041 Letairis users. Check the latest studies of Letairis.

On Jul, 19, 2026

14 people who take Mefenamic acid and Letairis together, and have interactions are studied.

Mefenamic acid and Letairis drug interactions.

What are the common drug interactions of Mefenamic Acid and Letairis, by gender? *:

female:

Headache (pain in head)
Dyspnoea (difficult or laboured respiration)
Palpitations (feelings or sensations that your heart is pounding or racing)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bowel movement irregularity
Death
Dizziness
Fatigue (feeling of tiredness)
Loss of consciousness
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

male:

n/a

What are the common drug interactions of Mefenamic Acid and Letairis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Headache (pain in head)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)

20-29:

n/a

30-39:

Loss of consciousness
Overdose
Bowel movement irregularity

40-49:

n/a

50-59:

Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

60+:

Oedema (fluid collection in tissue)
Hepatomegaly (abnormal enlargement of the liver)
Liver disorder (liver diseases)
Palpitations (feelings or sensations that your heart is pounding or racing)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Dizziness
Poor quality sleep

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 50.00%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 3 people, 21.43%
Systemic Sclerosis (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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