Mefoxin and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mefoxin (cefoxitin sodium) and Zofran (ondansetron hydrochloride). Common drug interactions include cor pulmonale chronic among females and laryngeal oedema among males.

The phase IV clinical study analyzes what interactions people have when they take Mefoxin and Zofran. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Mefoxin?

Mefoxin has active ingredients of cefoxitin sodium. eHealthMe is studying from 280 Mefoxin users. Check the latest studies of Mefoxin.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

45 people who take Mefoxin and Zofran together, and have interactions are studied.

What are the common drug interactions of Mefoxin and Zofran, by gender? *:

female:

Cor pulmonale chronic (long lasting enlargement of the right ventricle of the heart)
Gastroduodenitis (an inflammation of the mucous membrane of the stomach and duodenum)
Uterine enlargement
Cardiac failure congestive
Abdominal pain
Fatigue (feeling of tiredness)
Diarrhoea
Pleural effusion (water on the lungs)
Appendicitis (inflammation of the appendix)
Aptyalism (deficiency or absence of saliva)

male:

Laryngeal oedema (swelling of larynx)
Blood bilirubin increased
Small intestinal obstruction (blockage in small intestine)
Wound infection
Blood creatinine increased
Blood urea increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Colitis ulcerative (inflammation of colon with ulcer)
Fatigue (feeling of tiredness)
Haemolytic anaemia (anaemia due to haemolysis)

What are the common drug interactions of Mefoxin and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Colitis ulcerative (inflammation of colon with ulcer)
Small intestinal obstruction (blockage in small intestine)
Wound infection

20-29:

Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Activated partial thromboplastin time prolonged
Ascites (accumulation of fluid in the abdominal cavity)
Blood fibrinogen increased
Blood triglycerides increased
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Confusional state
Cough
Diarrhoea

40-49:

Abdominal distension
Abdominal pain
Device dislocation
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)
Uterine haemorrhage (uterine bleeding)
Haemangioma of skin (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)

50-59:

Osteonecrosis of jaw (death of bone of jaw)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Hyperglycaemia (high blood sugar)
Foot deformity (functional disability of foot)
Otitis externa (external ear infection)
Anxiety
Cor pulmonale chronic (long lasting enlargement of the right ventricle of the heart)
Gastroduodenitis (an inflammation of the mucous membrane of the stomach and duodenum)
Uterine enlargement
Weight decreased

60+:

Abdominal infection
Enterocutaneous fistula
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Colon cancer
Hepatic steatosis (fatty liver disease)
Metastatic lymphoma (spreadable cancer tumour of lymph node)
Pancreatitis acute (sudden inflammation of pancreas)
Pancreatitis relapsing
Weakness

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 27 people, 60.00%
Osteoporosis (bones weak and more likely to break): 27 people, 60.00%
Thrombocytopenia (decrease of platelets in blood): 11 people, 24.44%
Pain: 6 people, 13.33%
Depression: 6 people, 13.33%
Nausea And Vomiting: 5 people, 11.11%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 6.67%
Migraine Without Aura (headache without neurological problems): 3 people, 6.67%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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