Megace and Gemfibrozil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Megace (megestrol acetate) and Gemfibrozil (gemfibrozil). Common drug interactions include pain among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Megace and Gemfibrozil. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Megace?

Megace has active ingredients of megestrol acetate. It is often used in weight loss. eHealthMe is studying from 10,095 Megace users. Check the latest studies of Megace.

What is Gemfibrozil?

Gemfibrozil has active ingredients of gemfibrozil. It is often used in high blood cholesterol. eHealthMe is studying from 18,213 Gemfibrozil users. Check the latest studies of Gemfibrozil.

On Jul, 09, 2026

35 people who take Megace and Gemfibrozil together, and have interactions are studied.

Megace and Gemfibrozil drug interactions.

What are the common drug interactions of Megace and Gemfibrozil, by gender? *:

female:

Pain
Reflux oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus)
Rib fracture
Sinus headache (headache caused by sinus infections)
Sinusitis (inflammation of sinus)
Spinal column stenosis (narrowing of spinal column)
Toothache (tooth pain)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation)
Back pain

male:

Nausea (feeling of having an urge to vomit)
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Weight decreased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Back pain
Bone density decreased
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Megace and Gemfibrozil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Abdominal pain
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Anxiety
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Arthralgia (joint pain)
Asthma
Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Back pain

50-59:

Pain
Renal failure (kidney dysfunction)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hypotension (abnormally low blood pressure)
Neutropenia (an abnormally low number of neutrophils)
Osteopenia (a condition where bone mineral density is lower than normal)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)

60+:

Diarrhoea
Asthenia (weakness)
Bone neoplasm malignant (cancer of bone)
Death
Decreased interest
Disability
Dizziness
Duodenitis (inflammation of the duodenum)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Urticaria (rash of round, red welts on the skin that itch intensely): 5 people, 14.29%
High Blood Pressure: 5 people, 14.29%
Otitis (ear infection): 4 people, 11.43%
Nausea (feeling of having an urge to vomit): 4 people, 11.43%
Pain: 4 people, 11.43%
Hypertriglyceridaemia (excess of triglycerides in the blood): 3 people, 8.57%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.57%
Itching: 3 people, 8.57%
Folliculitis (infection of hair root): 3 people, 8.57%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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