Megace and Levoxyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Megace (megestrol acetate) and Levoxyl (levothyroxine sodium). Common drug interactions include staphylococcal infection among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Megace and Levoxyl. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Megace?

Megace has active ingredients of megestrol acetate. It is often used in weight loss. eHealthMe is studying from 10,095 Megace users. Check the latest studies of Megace.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

On Jul, 14, 2026

71 people who take Megace and Levoxyl together, and have interactions are studied.

What are the common drug interactions of Megace and Levoxyl, by gender? *:

female:

Staphylococcal infection (an infection with staphylococcus bacteria)
Swelling
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone disorder
Bruxism (habitual grinding of the teeth, typically during sleep)
Cellulitis (infection under the skin)
Culture urine positive
Depression
Disability
Ear pain

male:

Pneumonia
Fatigue (feeling of tiredness)
Dehydration (dryness resulting from the removal of water)
Dizziness
Dyspnoea (difficult or laboured respiration)
Malignant neoplasm progression (cancer tumour came back)
Oedema peripheral (superficial swelling)
Radiation necrosis (death of cell due to radiation)
Renal failure chronic (long lasting kidney dysfunction)
Abasia (inability to walk)

What are the common drug interactions of Megace and Levoxyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Radiation necrosis (death of cell due to radiation)
Meningioma (a diverse set of tumours arising from the meninges)
Acute respiratory distress syndrome
Age indeterminate myocardial infarction (age indeterminate heart attack)
Arrhythmia (irregular heartbeat)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Blindness
Blood pressure systolic decreased
Blood sodium decreased

50-59:

Nephrogenic fibrosing dermopathy (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain in extremity
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Skin exfoliation (removal of the oldest dead skin cells)
Skin hypertrophy (skin cells enlarges)
Throat irritation
Vomiting
Abasia (inability to walk)
Abdominal discomfort
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)

60+:

Pneumonia
Anaemia (lack of blood)
Cellulitis (infection under the skin)
Depression
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Injury
Swelling
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 7 people, 9.86%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 8.45%
High Blood Cholesterol: 5 people, 7.04%
Brain Cancer Metastatic: 5 people, 7.04%

* Approximation only. Some reports may have incomplete information.

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