Megace and Norvir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Megace (megestrol acetate) and Norvir (ritonavir). Common drug interactions include depression among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Megace and Norvir. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Megace?

Megace has active ingredients of megestrol acetate. It is often used in weight loss. eHealthMe is studying from 10,095 Megace users. Check the latest studies of Megace.

What is Norvir?

Norvir has active ingredients of ritonavir. It is often used in hiv infection. eHealthMe is studying from 24,973 Norvir users. Check the latest studies of Norvir.

On Jul, 13, 2026

57 people who take Megace and Norvir together, and have interactions are studied.

What are the common drug interactions of Megace and Norvir, by gender? *:

female:

Depression
Dysstasia (difficulty in standing)
Foot fracture
Fracture
Hip fracture
Osteopenia (a condition where bone mineral density is lower than normal)
Chronic kidney disease
Adrenocortical insufficiency chronic (hormonal-disorder that occurs when the adrenal glands do not produce enough of certain hormones-chronic adrenocortical disorder)
Arthralgia (joint pain)
Bone density decreased

male:

Emotional distress
Pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypokalaemia (low potassium)
Multiple fractures
Abdominal distension
Anaemia (lack of blood)
Blood sodium decreased
Blood triglycerides increased
Bone loss

What are the common drug interactions of Megace and Norvir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Adrenocortical insufficiency chronic (hormonal-disorder that occurs when the adrenal glands do not produce enough of certain hormones-chronic adrenocortical disorder)
Anaemia (lack of blood)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Electrolyte imbalance
Fatigue (feeling of tiredness)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Pneumonia
Pyrexia (fever)

30-39:

Emotional distress
Pain
Anxiety
Bone density decreased
Renal failure (kidney dysfunction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Depression
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis (death of bone)
Osteoporosis (bones weak and more likely to break)

40-49:

Gait disturbance
Haematocrit decreased
Heart rate increased
Hip arthroplasty
Hypercholesterolaemia (high levels of cholesterol in the blood)
Irritability
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Nervousness
Night sweats (sweating in night)

50-59:

Emotional distress
Pain
Depression
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Fracture
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Intervertebral disc degeneration (spinal disc degeneration)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

60+:

n/a

What are the existing conditions these people have? *

Acquired Immunodeficiency Syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv)): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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