Megace and Septra ds drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Megace (megestrol acetate) and Septra ds (sulfamethoxazole; trimethoprim). Common drug interactions include asthenia among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Megace and Septra ds. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Megace?

Megace has active ingredients of megestrol acetate. It is often used in weight loss. eHealthMe is studying from 10,095 Megace users. Check the latest studies of Megace.

What is Septra ds?

Septra ds has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 2,349 Septra ds users. Check the latest studies of Septra ds.

On Jul, 16, 2026

12 people who take Megace and Septra ds together, and have interactions are studied.

What are the common drug interactions of Megace and Septra Ds, by gender? *:

female:

Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Bacteraemia (presence of bacteria in the blood)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Depression
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)

male:

Hypotension (abnormally low blood pressure)
Blood creatinine increased
Blood lactate dehydrogenase increased
Blood sodium decreased
Candidiasis (candidiasis or thrush is a fungal infection)
Cardiac arrest
Cholangitis (infection of the bile duct)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Depressed level of consciousness
Diarrhoea

What are the common drug interactions of Megace and Septra Ds, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

30-39:

Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Blood alkaline phosphatase nos increased
Blood creatinine increased
Blood lactate dehydrogenase increased
Blood sodium decreased
Cardiac arrest
Depressed level of consciousness
Diarrhoea
Dyspnoea (difficult or laboured respiration)

40-49:

Disease progression
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Metastases to lung (cancer spreads to lung)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Respiratory failure (inadequate gas exchange by the respiratory system)

50-59:

Asthenia (weakness)
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
Pallor
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

60+:

Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Cholangitis (infection of the bile duct)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Depression
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Drug effect decreased

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 8.33%
Pain: 1 person, 8.33%
Osteoporosis (bones weak and more likely to break): 1 person, 8.33%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 8.33%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 1 person, 8.33%
Bipolar Disorder (mood disorder): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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