Mekinist and Olanzapine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mekinist (trametinib dimethyl sulfoxide) and Olanzapine (olanzapine). Common drug interactions include death among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Mekinist and Olanzapine. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Mekinist?

Mekinist has active ingredients of trametinib dimethyl sulfoxide. eHealthMe is studying from 17,350 Mekinist users. Check the latest studies of Mekinist.

What is Olanzapine?

Olanzapine has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 69,242 Olanzapine users. Check the latest studies of Olanzapine.

On Jul, 16, 2026

22 people who take Mekinist and Olanzapine together, and have interactions are studied.

Mekinist and Olanzapine drug interactions.

What are the common drug interactions of Mekinist and Olanzapine, by gender? *:

female:

Death
Asthenia (weakness)
Bicytopenia (two parameters from the full blood count are low, the term bicytopenia can be used)
Confusional state
Dehydration (dryness resulting from the removal of water)
Dizziness
Dyspnoea (difficult or laboured respiration)
Electrolyte imbalance
Pain
Rash

male:

Pyrexia (fever)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Visual acuity reduced (reduced clearness of vision)
Peripheral swelling
Arthralgia (joint pain)
Chapped lips (cracking, fissuring, and peeling of the skin f lip)
Constipation
Death
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Mekinist and Olanzapine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Death
Hereditary angioedema (recurrent episodes of severe swelling)
Vomiting

10-19:

Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Pruritus (severe itching of the skin)

20-29:

n/a

30-39:

Abdominal pain
Constipation
Death
Diarrhoea
Gait disturbance
Hypokalaemia (low potassium)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Pain
Rash
Urticaria (rash of round, red welts on the skin that itch intensely)

40-49:

Death

50-59:

Pyrexia (fever)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Peripheral swelling
Abscess (pus)
Arthralgia (joint pain)
Blood pressure increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Feeling of despair
Headache (pain in head)
Hospitalisation

60+:

Asthenia (weakness)
Bicytopenia (two parameters from the full blood count are low, the term bicytopenia can be used)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Syncope (loss of consciousness with an inability to maintain postural tone)
Confusional state
Dizziness
Dyspnoea (difficult or laboured respiration)
Electrolyte imbalance
Death
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 8 people, 36.36%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 3 people, 13.64%
High Blood Pressure: 3 people, 13.64%
Type 2 Diabetes: 2 people, 9.09%
Thyroid Cancer: 2 people, 9.09%
Sleep Disorder: 2 people, 9.09%
Nausea (feeling of having an urge to vomit): 2 people, 9.09%
Malignant Peritoneal Neoplasm (cancer tumour of peritoneum): 2 people, 9.09%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 9.09%
Depression: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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