Melatonin and Adcal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Adcal (calcium carbonate). Common drug interactions include drug intolerance among females and arthritis among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Adcal. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,213 Melatonin users. Check the latest studies of Melatonin.

What is Adcal?

Adcal has active ingredients of calcium carbonate. eHealthMe is studying from 4,844 Adcal users. Check the latest studies of Adcal.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

23 people who take Melatonin and Adcal together, and have interactions are studied.

What are the common drug interactions of Melatonin and Adcal, by gender? *:

female:

Drug intolerance (drug sensitivity)
Somnolence (a state of near-sleep, a strong desire for sleep)
Respiratory tract infection
Anaemia (lack of blood)
Antipsychotic drug level increased
Asthma
Cardiac arrest
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)
Drug level increased
Lower respiratory tract infection

male:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Pyelonephritis (inflammation of kidney caused by bacteria)
Urinary tract infection
Diarrhoea
Malaise (a feeling of general discomfort or uneasiness)
Oropharyngeal pain
Osteomyelitis (infection of bone)
Rhinorrhoea (watery mucus discharge from the nose)
Tooth abscess (pus formation in tooth)

What are the common drug interactions of Melatonin and Adcal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)

20-29:

Abdominal pain

30-39:

n/a

40-49:

Antipsychotic drug level increased
Asthma
Cardiac arrest
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)
Drug level increased
Lower respiratory tract infection
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Respiratory disorder (respiratory disease)
Respiratory tract infection
Loss of consciousness

50-59:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Malaise (a feeling of general discomfort or uneasiness)
Oropharyngeal pain
Osteomyelitis (infection of bone)
Rhinorrhoea (watery mucus discharge from the nose)
Tooth abscess (pus formation in tooth)
Upper limb fracture
Haematoma (collection of blood outside the blood vessels)
Lower respiratory tract infection

60+:

Drug intolerance (drug sensitivity)
Somnolence (a state of near-sleep, a strong desire for sleep)
Femoral neck fracture (neck of femur bone fracture)
Neutropenia (an abnormally low number of neutrophils)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Thrombocytopenia (decrease of platelets in blood)
White blood cell count decreased
Anaemia (lack of blood)
Respiratory tract infection
Urinary tract infection

What are the existing conditions these people have? *

Pain: 12 people, 52.17%
Ill-Defined Disorder: 11 people, 47.83%
Depressed Mood: 9 people, 39.13%
Constipation: 9 people, 39.13%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 13.04%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 8.70%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 8.70%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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