Melatonin and Apidra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Apidra (insulin glulisine recombinant). Common drug interactions include blood pressure increased among females and hypoglycaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Apidra. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Apidra?

Apidra has active ingredients of insulin glulisine recombinant. It is often used in diabetes. eHealthMe is studying from 10,548 Apidra users. Check the latest studies of Apidra.



On Jul, 30, 2026

19 people who take Melatonin and Apidra together, and have interactions are studied.

Melatonin and Apidra drug interactions.

What are the common drug interactions of Melatonin and Apidra, by gender? *:

female:

  1. Blood pressure increased
  2. Dehydration (dryness resulting from the removal of water)
  3. Dizziness
  4. Headache (pain in head)
  5. Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)
  6. Nausea (feeling of having an urge to vomit)
  7. Palpitations (feelings or sensations that your heart is pounding or racing)
  8. Swelling
  9. Weight increased
  10. Sepsis (a severe blood infection that can lead to organ failure and death)

male:

  1. Hypoglycaemia (deficiency of glucose in the bloodstream)
  2. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  3. Adverse event
  4. Back injury
  5. Cardiac disorder
  6. Confusional state
  7. Death
  8. Drug hypersensitivity
  9. Impaired healing
  10. Lung neoplasm malignant (cancer tumour of lung)

What are the common drug interactions of Melatonin and Apidra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Subcutaneous abscess
  2. Abscess (pus)
  3. Abscess limb (limb infection)
  4. Cellulitis (infection under the skin)
  5. Escherichia sepsis (bacterial infection by escherichia coli)
  6. Groin abscess (pus in groin)
  7. Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
  8. Perineal abscess
  9. Perirectal abscess
  10. Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

  1. Alcoholic pancreatitis
  2. Back injury
  3. Cough
  4. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
  5. Drug dependence
  6. Head injury
  7. Hypotension (abnormally low blood pressure)
  8. Impaired healing
  9. Lung neoplasm malignant (cancer tumour of lung)
  10. Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)

60+:

  1. Blood pressure increased
  2. Dehydration (dryness resulting from the removal of water)
  3. Blood creatinine increased
  4. Drug intolerance (drug sensitivity)
  5. Dry skin
  6. Dyspnoea (difficult or laboured respiration)
  7. Fatigue (feeling of tiredness)
  8. Hallucination (an experience involving the perception of something not present)
  9. Heart rate decreased
  10. Heart rate increased

What are the existing conditions these people have? *

  1. Type 2 Diabetes: 5 people, 26.32%
  2. Cardiac Failure Chronic: 3 people, 15.79%
  3. Stress And Anxiety: 3 people, 15.79%
  4. Sleep Disorder: 3 people, 15.79%
  5. Depression: 3 people, 15.79%
  6. Pain: 3 people, 15.79%
  7. Multiple Myeloma (cancer of the plasma cells): 3 people, 15.79%
  8. Weight Decreased: 2 people, 10.53%
  9. Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 10.53%
  10. Blood Pressure Abnormal: 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Melatonin and Apidra?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Melatonin and Apidra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Melatonin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Apidra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Melatonin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Apidra and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on melatonin and insulin glulisine recombinant (the active ingredients of Melatonin and Apidra, respectively), and Melatonin and Apidra (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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