Melatonin and Atomoxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Atomoxetine (atomoxetine). Common drug interactions include pyrexia among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Atomoxetine. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,213 Melatonin users. Check the latest studies of Melatonin.

What is Atomoxetine?

Atomoxetine has active ingredients of atomoxetine. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,363 Atomoxetine users. Check the latest studies of Atomoxetine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

50 people who take Melatonin and Atomoxetine together, and have interactions are studied.

Melatonin and Atomoxetine drug interactions.

What are the common drug interactions of Melatonin and Atomoxetine, by gender? *:

female:

Pyrexia (fever)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Shunt malfunction
Shunt occlusion (blockage of shunt)
Stress
Swelling
Viral diarrhoea
Vomiting
Abdominal discomfort
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

male:

Agitation (state of anxiety or nervous excitement)
Vomiting
Eructation (release of gas from the digestive tract)
Eye movement disorder
Fall
Foot deformity (functional disability of foot)
Gait disturbance
Gastric hypomotility (less movement of stomach)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Influenza

What are the common drug interactions of Melatonin and Atomoxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Bradycardia (abnormally slow heart action)
Delusion (a false belief or opinion)
Fatigue (feeling of tiredness)
Nightmare (unpleasant dream)

10-19:

Agitation (state of anxiety or nervous excitement)
Abdominal pain
Blood growth hormone increased
Brain injury
Chest pain
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Diarrhoea
Eructation (release of gas from the digestive tract)

20-29:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Anaemia (lack of blood)
Gastric varices
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hospitalisation
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Type 1 diabetes mellitus

30-39:

Dyspnoea (difficult or laboured respiration)
Heart rate increased

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Delusion (a false belief or opinion)
Emotional distress
Hostility
Irritability
Mania (a state of abnormally elevated or irritable mood)
Pain
Verbal abuse (abusive behaviour involving the use of language)
Anxiety

50-59:

Abdominal discomfort
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Agitation (state of anxiety or nervous excitement)
Anxiety
Head discomfort
Hypervigilance
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

60+:

Localised infection (infection at the single location)

What are the existing conditions these people have? *

Pituitary Tumor: 14 people, 28.00%
Growth Hormone-Producing Pituitary Tumor: 14 people, 28.00%
Constipation: 14 people, 28.00%
Tremor (trembling or shaking movements in one or more parts of your body): 7 people, 14.00%
Urticaria (rash of round, red welts on the skin that itch intensely): 6 people, 12.00%
Rickets (softening of bones): 5 people, 10.00%
Lipodystrophy Acquired (a regional loss of subcutaneous adipose tissue which usually starts in the face, extends downward acquired): 5 people, 10.00%
Itching: 5 people, 10.00%
Autoimmune Hepatitis: 5 people, 10.00%
Viral Skin Infection: 4 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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