Melatonin and Bydureon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Bydureon (exenatide synthetic). Common drug interactions include fatigue among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Bydureon. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,213 Melatonin users. Check the latest studies of Melatonin.

What is Bydureon?

Bydureon has active ingredients of exenatide synthetic. It is often used in type 2 diabetes. eHealthMe is studying from 24,309 Bydureon users. Check the latest studies of Bydureon.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Sep, 03, 2026

65 people who take Melatonin and Bydureon together, and have interactions are studied.

Melatonin and Bydureon drug interactions.

What are the common drug interactions of Melatonin and Bydureon, by gender? *:

female:

  1. Fatigue (feeling of tiredness)
  2. Perirectal abscess
  3. Glycosylated haemoglobin increased
  4. Ageusia (loss of taste functions of the tongue)
  5. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  6. Arthralgia (joint pain)
  7. Bone pain
  8. Contusion (a type of hematoma of tissue in which capillaries)
  9. Dyskinesia (abnormality or impairment of voluntary movement)
  10. Gastric hypomotility (less movement of stomach)

male:

  1. Renal failure (kidney dysfunction)
  2. Essential hypertension (primary hypertension)
  3. Memory impairment
  4. Perineal abscess
  5. Rash
  6. Scrotal abscess (pus in scrotum)
  7. Abdominal pain lower
  8. Anal abscess
  9. Dry eye (lack of adequate tears)
  10. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)

What are the common drug interactions of Melatonin and Bydureon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Chronic kidney disease
  2. Limb discomfort (discomfort in leg)
  3. Renal failure (kidney dysfunction)
  4. Renal injury (kidney injury)

40-49:

  1. Cellulitis (infection under the skin)
  2. Groin abscess (pus in groin)
  3. Perineal abscess
  4. Ageusia (loss of taste functions of the tongue)
  5. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  6. Arthralgia (joint pain)
  7. Bone pain
  8. Chronic kidney disease
  9. Contusion (a type of hematoma of tissue in which capillaries)
  10. Diarrhoea

50-59:

  1. Arthralgia (joint pain)
  2. Blood glucose decreased
  3. Blood glucose increased
  4. Diabetes mellitus inadequate control
  5. Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
  6. Essential hypertension (primary hypertension)
  7. Glycosylated haemoglobin increased
  8. Impaired healing
  9. Infection
  10. Injection site reaction

60+:

  1. Injection site haemorrhage (bleeding from injection site)
  2. Depression
  3. Inflammatory bowel disease
  4. Injection site haematoma (localized swelling filled with blood at injection site)
  5. Proctitis (inflammation of the rectum and anus)
  6. Anxiety
  7. Fatigue (feeling of tiredness)
  8. Injection site mass
  9. Pain
  10. Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

  1. Diabetes: 20 people, 30.77%
  2. High Blood Cholesterol: 18 people, 27.69%
  3. Depression: 14 people, 21.54%
  4. Fluid Retention (an abnormal accumulation of fluid in the blood): 8 people, 12.31%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 12.31%
  6. Weight Decreased: 7 people, 10.77%
  7. Sleep Disorder: 7 people, 10.77%
  8. Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 7 people, 10.77%
  9. Cardiac Disorder: 7 people, 10.77%
  10. High Blood Pressure: 6 people, 9.23%

* Approximation only. Some reports may have incomplete information.

Do you take Melatonin and Bydureon?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Melatonin and Bydureon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Melatonin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Bydureon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Melatonin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Bydureon and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on melatonin and exenatide synthetic (the active ingredients of Melatonin and Bydureon, respectively), and Melatonin and Bydureon (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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