Melatonin and Hycodan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Hycodan (homatropine methylbromide; hydrocodone bitartrate). Common drug interactions include fatigue among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Hycodan. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Hycodan?

Hycodan has active ingredients of homatropine methylbromide; hydrocodone bitartrate. It is often used in cough. eHealthMe is studying from 769 Hycodan users. Check the latest studies of Hycodan.

On Jul, 07, 2026

22 people who take Melatonin and Hycodan together, and have interactions are studied.

Melatonin and Hycodan drug interactions.

What are the common drug interactions of Melatonin and Hycodan, by gender? *:

female:

Fatigue (feeling of tiredness)
Infusion related reaction
Asthma
Diarrhoea
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Mycobacterium avium complex infection
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Osteoporosis (bones weak and more likely to break)
Pneumonia

male:

Pneumonia
Blood pressure increased
Atelectasis (partial or complete collapse of the lung)
Back pain
Balance disorder
Benign neoplasm of skin (benign (non-cancerous) tumours of the skin)
Chest pain
Cytomegalovirus colitis (an inflammation of the colon from virus)
Decreased appetite
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)

What are the common drug interactions of Melatonin and Hycodan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Csf neutrophil count increased
Csf white blood cell count increased
Dizziness
Drug effect decreased
Fatigue (feeling of tiredness)
Headache (pain in head)
Hemiparesis (weakness on one side of the body)
Hypoaesthesia (reduced sense of touch or sensation)
Nausea (feeling of having an urge to vomit)

40-49:

n/a

50-59:

Dyspnoea (difficult or laboured respiration)
Blood pressure increased
Chest discomfort
Chest pain
Increased appetite
Leukopenia (less number of white blood cells in blood)
Oedema peripheral (superficial swelling)
Transplant rejection (a transplant material is not worked)

60+:

Asthenia (weakness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Malaise (a feeling of general discomfort or uneasiness)
Respiratory failure (inadequate gas exchange by the respiratory system)
Uveitis (inflammation of the uvea)
Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system)
Therapeutic response unexpected
Weight increased
Acute respiratory failure
Atelectasis (partial or complete collapse of the lung)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 5 people, 22.73%
Constipation: 4 people, 18.18%
Nausea (feeling of having an urge to vomit): 4 people, 18.18%
High Blood Pressure: 3 people, 13.64%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 13.64%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 13.64%
Depression: 3 people, 13.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.64%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 13.64%
Pain: 3 people, 13.64%

* Approximation only. Some reports may have incomplete information.

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