Melatonin and Mint drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Mint (peppermint). Common drug interactions include tremor among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Mint. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Mint?

Mint has active ingredients of peppermint. eHealthMe is studying from 1,344 Mint users. Check the latest studies of Mint.

On Jul, 10, 2026

60 people who take Melatonin and Mint together, and have interactions are studied.

What are the common drug interactions of Melatonin and Mint, by gender? *:

female:

Tremor (trembling or shaking movements in one or more parts of your body)
Anaemia (lack of blood)
Dizziness
Mobility decreased (ability to move is reduced)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Swelling
Weight decreased
Bacterial infection
Oedema (fluid collection in tissue)
Respiratory disorder (respiratory disease)

male:

Fatigue (feeling of tiredness)
Headache (pain in head)
Blood lactate dehydrogenase increased
Blood phosphorus decreased
Blood potassium decreased
Blood sodium decreased
Blood triglycerides increased
C-reactive protein increased
Coagulopathy (blood's ability to clot is impaired)
Confusional state

What are the common drug interactions of Melatonin and Mint, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Device dislocation
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Weight gain poor

10-19:

Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood albumin decreased
Blood alkaline phosphatase decreased
Blood calcium decreased
Blood glucose increased
Blood immunoglobulin g decreased
Blood lactate dehydrogenase increased
Blood phosphorus decreased

20-29:

Back pain
Burning sensation
Dizziness
Headache (pain in head)
Hypersensitivity
Mucous stools (mucous with stool)
Nasal obstruction (blockage of nose)
Pain in extremity
Painful respiration
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

30-39:

Abdominal discomfort
Abnormal behaviour
Alanine aminotransferase increased
Anaemia (lack of blood)
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Aspartate aminotransferase increased
Asthma
Bacterial infection
Blood bilirubin increased

40-49:

Asthma
Cardiac arrest
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)
Antipsychotic drug level increased
Drug level increased
Lower respiratory tract infection
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Respiratory disorder (respiratory disease)
Respiratory tract infection

50-59:

Circadian rhythm sleep disorder (family of sleep disorders affecting, among other things, the timing of sleep)
Constipation
Cystitis interstitial (unknown cause characterized by bladder pain)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Dysphonia (speech disorder attributable to a disorder of phonation)
Ejection fraction decreased (systolic heart failure)
Eye disorder
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)

60+:

Asthenia (weakness)
Blood pressure increased
Pyrexia (fever)
Urinary tract infection
Abdominal pain
Adverse drug reaction
Ageusia (loss of taste functions of the tongue)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Anger

What are the existing conditions these people have? *

Pain: 14 people, 23.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 16.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 15.00%
Sleep Disorder: 7 people, 11.67%
Immunodeficiency Common Variable: 6 people, 10.00%
Diabetes: 6 people, 10.00%
High Blood Pressure: 6 people, 10.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 8.33%
Rashes (redness): 5 people, 8.33%
Pituitary-Dependent Cushing's Syndrome (pituitary dependent hypercortisolism): 5 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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