Melatonin and Nattokinase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Nattokinase (nattokinase). Common drug interactions include supraventricular tachycardia among females and anaesthetic complication among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Nattokinase. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Nattokinase?

Nattokinase has active ingredients of nattokinase. It is often used in blood clots. eHealthMe is studying from 227 Nattokinase users. Check the latest studies of Nattokinase.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

21 people who take Melatonin and Nattokinase together, and have interactions are studied.

Melatonin and Nattokinase drug interactions.

What are the common drug interactions of Melatonin and Nattokinase, by gender? *:

female:

Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Cough
Dizziness
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Myalgia (muscle pain)
Red blood cell sedimentation rate increased
Alpha 1 globulin increased
Alpha 2 globulin increased

male:

Anaesthetic complication
Colorectal cancer (colon cancer or bowel cancer)
Death
Abdominal distension
Anaemia (lack of blood)
Fatigue (feeling of tiredness)
Oedema (fluid collection in tissue)
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Melatonin and Nattokinase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Anaesthetic complication
Colorectal cancer (colon cancer or bowel cancer)

60+:

Death
Myalgia (muscle pain)
Fatigue (feeling of tiredness)
Gait disturbance
Headache (pain in head)
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))
Lymphocyte count decreased
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain
Pain in extremity

What are the existing conditions these people have? *

Headache (pain in head): 5 people, 23.81%
Type 2 Diabetes: 4 people, 19.05%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 4 people, 19.05%
Cardiac Disorder: 4 people, 19.05%
Constipation: 4 people, 19.05%
Cryofibrinogenaemia (the presence of cryofibrinogen in the blood): 4 people, 19.05%
Depression: 4 people, 19.05%
Diabetes: 4 people, 19.05%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 4 people, 19.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 19.05%

* Approximation only. Some reports may have incomplete information.

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