Melatonin and Primaxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Primaxin (cilastatin sodium; imipenem). Common drug interactions include adrenal insufficiency among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Primaxin. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,213 Melatonin users. Check the latest studies of Melatonin.

What is Primaxin?

Primaxin has active ingredients of cilastatin sodium; imipenem. eHealthMe is studying from 4,540 Primaxin users. Check the latest studies of Primaxin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

18 people who take Melatonin and Primaxin together, and have interactions are studied.

Melatonin and Primaxin drug interactions.

What are the common drug interactions of Melatonin and Primaxin, by gender? *:

female:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia of chronic disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Arthropathy
Balanoposthitis (inflammation of the glands penis and the foreskin)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)

male:

Abdominal pain upper
Abscess jaw (tooth abscess or root abscess)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone swelling
Cough
Dental fistula
Disability
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Dyspepsia (indigestion)

What are the common drug interactions of Melatonin and Primaxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal distension
Abdominal pain upper
Abscess jaw (tooth abscess or root abscess)
Actinomycosis (infection that causes sores, or abscesses)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia of chronic disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Impaired gastric emptying
Implant site infection
Lethargy (tiredness)
Nausea (feeling of having an urge to vomit)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Renal failure (kidney dysfunction)
Septic shock (shock due to blood infection)
Vomiting
Abdominal pain
Alanine aminotransferase decreased

60+:

Abdominal pain upper
Abscess jaw (tooth abscess or root abscess)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone swelling
Cough
Dental fistula
Disability
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Dyspepsia (indigestion)

What are the existing conditions these people have? *

Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries)): 15 people, 83.33%
Gynecomastia (enlargement of the gland tissue of the male breast): 15 people, 83.33%
Osteopenia (a condition where bone mineral density is lower than normal): 13 people, 72.22%
Mycobacterium Abscessus Infection (rapid growing bacterial infection): 3 people, 16.67%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 5.56%
Diabetes: 1 person, 5.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.56%
Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 5.56%
Heart Attack: 1 person, 5.56%
High Blood Pressure: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Melatonin and Primaxin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously