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Melatonin and Probenecid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Probenecid (probenecid). Common drug interactions include seizure among females and ear discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Probenecid. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Probenecid?

Probenecid has active ingredients of probenecid. It is often used in gout. eHealthMe is studying from 560 Probenecid users. Check the latest studies of Probenecid.

On Jul, 19, 2026

14 people who take Melatonin and Probenecid together, and have interactions are studied.

Melatonin and Probenecid drug interactions.

What are the common drug interactions of Melatonin and Probenecid, by gender? *:

female:

  1. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  2. Death

male:

  1. Ear discomfort
  2. Increased upper airway secretion
  3. Productive cough
  4. Dysphagia (a condition in which swallowing is difficult or painful)
  5. Fall
  6. Hospitalisation
  7. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the common drug interactions of Melatonin and Probenecid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Seizure (abnormal excessive or synchronous neuronal activity in the brain)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Ear discomfort
  2. Increased upper airway secretion
  3. Productive cough
  4. Death
  5. Dysphagia (a condition in which swallowing is difficult or painful)
  6. Fall
  7. Hospitalisation
  8. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the existing conditions these people have? *

  1. Nephropathy Toxic (damage to kidney due to toxins): 9 people, 64.29%
  2. Nausea And Vomiting: 9 people, 64.29%
  3. Haemorrhage (bleeding): 9 people, 64.29%
  4. Ureteritis (inflammation of the ureter): 8 people, 57.14%
  5. Stress And Anxiety: 8 people, 57.14%
  6. Pain: 8 people, 57.14%
  7. Nausea (feeling of having an urge to vomit): 8 people, 57.14%
  8. Hallucinations (sensations that appear real but are created by your mind): 2 people, 14.29%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 14.29%
  10. Delusion (a false belief or opinion): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Melatonin and Probenecid?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Melatonin and Probenecid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Melatonin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Probenecid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Melatonin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Probenecid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on melatonin and probenecid (the active ingredients of Melatonin and Probenecid, respectively), and Melatonin and Probenecid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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