Melatonin and Robaxisal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Robaxisal (aspirin; methocarbamol). Common drug interactions include muscle spasms among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Robaxisal. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Robaxisal?

Robaxisal has active ingredients of aspirin; methocarbamol. It is often used in back pain. eHealthMe is studying from 223 Robaxisal users. Check the latest studies of Robaxisal.

On Aug, 06, 2026

97 people who take Melatonin and Robaxisal together, and have interactions are studied.

Melatonin and Robaxisal drug interactions.

What are the common drug interactions of Melatonin and Robaxisal, by gender? *:

female:

Muscle spasms (muscle contraction)
Anxiety
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Autism spectrum disorder (developmental disabilities that can cause significant social, communication and behavioural challenges)
Blood pressure diastolic decreased
Body temperature increased
Decreased appetite
Exostosis (formation of new bone on the surface of a bone)
Headache (pain in head)
Heart rate increased

male:

Drug dependence
Epidural lipomatosis (excessive accumulation of fat within the epidural space -brain)
Juvenile idiopathic arthritis (a subset of arthritis seen in childhood)
Obesity (having too much body fat)
Respiratory depression (respiration has a rate below 12 breaths)
Drug ineffective
Drug abuse
Victim of child abuse
Child abuse
Tenderness (pain or discomfort when an affected area is touched)

What are the common drug interactions of Melatonin and Robaxisal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug dependence
Epidural lipomatosis (excessive accumulation of fat within the epidural space -brain)
Juvenile idiopathic arthritis (a subset of arthritis seen in childhood)
Obesity (having too much body fat)
Respiratory depression (respiration has a rate below 12 breaths)
Drug ineffective
Drug abuse
Victim of child abuse
Child abuse
Tenderness (pain or discomfort when an affected area is touched)

20-29:

n/a

30-39:

Body temperature increased
Decreased appetite
Exostosis (formation of new bone on the surface of a bone)
Headache (pain in head)
Heart rate increased
Hypotension (abnormally low blood pressure)
Influenza like illness
Infusion related reaction
Intervertebral disc degeneration (spinal disc degeneration)
Jaw disorder (jaw disease)

40-49:

Cerebellar ataxia (loss of coordination)

50-59:

Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
Lupus-like syndrome (a disease symptom matches with lupus an immune disease)
Muscle spasms (muscle contraction)
Myalgia (muscle pain)

60+:

n/a

What are the existing conditions these people have? *

Pain: 90 people, 92.78%
Itching: 90 people, 92.78%
Constipation: 90 people, 92.78%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 89 people, 91.75%
Muscle Spasms (muscle contraction): 85 people, 87.63%
Child Abuse: 84 people, 86.60%
Sleep Disorder: 81 people, 83.51%
Precocious Puberty: 10 people, 10.31%
Muscle Tightness: 5 people, 5.15%
Headache (pain in head): 5 people, 5.15%

* Approximation only. Some reports may have incomplete information.

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