Melatonin and Sodium fluoride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Sodium fluoride (fluoride). Common drug interactions include stomatitis among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Sodium fluoride. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Sodium fluoride?

Sodium fluoride has active ingredients of fluoride. It is often used in dental cavities. eHealthMe is studying from 1,216 Sodium fluoride users. Check the latest studies of Sodium fluoride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

75 people who take Melatonin and Sodium fluoride together, and have interactions are studied.

Melatonin and Sodium fluoride drug interactions.

What are the common drug interactions of Melatonin and Sodium Fluoride, by gender? *:

female:

Stomatitis (inflammation of mucous membrane of mouth)
Abdominal discomfort
Abdominal distension
Abdominal pain
Alopecia (absence of hair from areas of the body)
Aphasia (damage to the parts of the brain that control language)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Ascites (accumulation of fluid in the abdominal cavity)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Back disorder

male:

Fall
Hospitalisation
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nasopharyngitis (inflammation of the nasopharynx)
Pneumonia
Rectal haemorrhage (bleeding from anus)
Renal failure (kidney dysfunction)
Urinary tract infection enterococcal
Vision blurred
Apathy

What are the common drug interactions of Melatonin and Sodium Fluoride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Electrocardiogram qt prolonged
Hospitalisation
Infection
Rhinovirus infection
Urinary tract infection
Chronic kidney disease
Constipation
Dysphagia (a condition in which swallowing is difficult or painful)
Febrile neutropenia (fever with reduced white blood cells)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

20-29:

Hepatobiliary disease (diseases affect the liver and/or biliary tract)
Abdominal pain

30-39:

Anxiety
Bone density decreased
Emotional distress
Nephropathy (damage to or disease of a kidney)
Pain
Renal failure (kidney dysfunction)
Tooth loss
Rash

40-49:

Anxiety
Colitis (inflammation of colon)
Drug ineffective
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Alopecia (absence of hair from areas of the body)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Back disorder
Breast cancer stage iii

50-59:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Neck pain
Pneumonia
Rectal haemorrhage (bleeding from anus)
Urinary tract infection
Urinary tract infection enterococcal
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Blood urine present
Haematochezia (passage of stools containing blood)
Testicular mass (mass on testes)

60+:

Fall
Asthenia (weakness)
Dental caries
Depression
Dizziness
Drug ineffective
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Haemorrhage (bleeding)

What are the existing conditions these people have? *

Pain: 28 people, 37.33%
Sleep Disorder: 16 people, 21.33%
Depression: 15 people, 20.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 13.33%
Back Pain: 10 people, 13.33%
Muscle Spasms (muscle contraction): 9 people, 12.00%
Hypersensitivity: 9 people, 12.00%
Constipation: 9 people, 12.00%
Metastases To Bone (cancer spreads to bone): 9 people, 12.00%
Neuralgia (pain in one or more nerves): 9 people, 12.00%

* Approximation only. Some reports may have incomplete information.

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