Melatonin and Tylenol w/ codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Tylenol w/ codeine (acetaminophen; codeine phosphate). Common drug interactions include abdominal discomfort among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Tylenol w/ codeine. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

On Jul, 10, 2026

12 people who take Melatonin and Tylenol w/ codeine together, and have interactions are studied.

Melatonin and Tylenol w/ codeine drug interactions.

What are the common drug interactions of Melatonin and Tylenol W/ Codeine, by gender? *:

female:

Abdominal discomfort
Abdominal pain
Abdominal pain upper
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Nausea (feeling of having an urge to vomit)
Vomiting
Anxiety
Cataract (clouding of the lens inside the eye)

male:

Anaemia (lack of blood)
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries))
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

What are the common drug interactions of Melatonin and Tylenol W/ Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Abdominal pain
Abdominal pain upper
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Nausea (feeling of having an urge to vomit)
Vomiting

30-39:

Oedema peripheral (superficial swelling)
Pain in extremity
Thrombosis (formation of a blood clot inside a blood vessel)
Cataract (clouding of the lens inside the eye)
Glaucoma (increased fluid pressure in the eye with vision loss)

40-49:

n/a

50-59:

Confusional state
Incontinence (lack of moderation or self-control)
Lethargy (tiredness)
Accidental exposure
Unresponsive to stimuli
Depressed level of consciousness
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Anaemia (lack of blood)

What are the existing conditions these people have? *

Accidental Exposure: 3 people, 25.00%
High Blood Cholesterol: 2 people, 16.67%
Depression: 2 people, 16.67%
Bone Pain: 1 person, 8.33%
Breakthrough Pain: 1 person, 8.33%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 8.33%
Drowsiness: 1 person, 8.33%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%
Weight Decreased: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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