Melatonin and Vitamin b2 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Vitamin b2 (riboflavin). Common drug interactions include muscular weakness among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Vitamin b2. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Vitamin b2?

Vitamin b2 has active ingredients of riboflavin. It is often used in migraine. eHealthMe is studying from 1,740 Vitamin b2 users. Check the latest studies of Vitamin b2.

On Jul, 06, 2026

79 people who take Melatonin and Vitamin b2 together, and have interactions are studied.

Melatonin and Vitamin b2 drug interactions.

What are the common drug interactions of Melatonin and Vitamin B2, by gender? *:

female:

Muscular weakness (muscle weakness)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Peroneal nerve palsy
Rash
Restless legs syndrome (a powerful urge to move your legs)
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Retinopathy (acute damage to the retina of the eye)
Sinusitis (inflammation of sinus)
Stress
Tinnitus (a ringing in the ears)

male:

Diarrhoea
Asthenia (weakness)
C-reactive protein increased
Cataract (clouding of the lens inside the eye)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Chronic kidney disease
Confusional state
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Disease progression

What are the common drug interactions of Melatonin and Vitamin B2, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Diarrhoea
Gastric infection (infection of stomach)
Impaired gastric emptying
Irritability
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Pain
Vomiting

20-29:

Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Retinopathy (acute damage to the retina of the eye)
Vision blurred
Vitreous floaters (spots before the eyes)
Vitreous haemorrhage (intraocular (inside the eye) bleeding)
Anxiety
Arthralgia (joint pain)
Hallucination (an experience involving the perception of something not present)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Infusion related reaction

30-39:

Nausea (feeling of having an urge to vomit)
Somnolence (a state of near-sleep, a strong desire for sleep)
Diarrhoea
Dizziness
Eating disorder
Eye pain
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Headache (pain in head)
Muscle twitching
Muscular weakness (muscle weakness)

40-49:

Diarrhoea
Headache (pain in head)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Neck pain
Dyspnoea exertional (breathlessness or shortness of breath)
Pallor
Palpitations (feelings or sensations that your heart is pounding or racing)
Syncope (loss of consciousness with an inability to maintain postural tone)
Abdominal distension
Abdominal pain upper

50-59:

Dysphonia (speech disorder attributable to a disorder of phonation)
Fatigue (feeling of tiredness)
Joint stiffness
Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Neck pain
Nystagmus (a condition of involuntary eye movement)
Oral discomfort (pain or irritation in mouth)
Palpitations (feelings or sensations that your heart is pounding or racing)

60+:

Fall
Confusional state
Blood creatine phosphokinase increased
Brain stem infarction (brainstem stroke)
Circulatory collapse
Dehydration (dryness resulting from the removal of water)
Dementia (madness)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 15.19%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 13.92%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 10.13%
Pain: 6 people, 7.59%
Stress And Anxiety: 5 people, 6.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 6.33%
Constipation: 5 people, 6.33%
High Blood Cholesterol: 4 people, 5.06%
Drowsiness: 4 people, 5.06%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 5.06%

* Approximation only. Some reports may have incomplete information.

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