Melatonin and Zelnorm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melatonin (melatonin) and Zelnorm (tegaserod maleate). Common drug interactions include abdominal pain among females.

The phase IV clinical study analyzes what interactions people have when they take Melatonin and Zelnorm. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

What is Zelnorm?

Zelnorm has active ingredients of tegaserod maleate. eHealthMe is studying from 7,261 Zelnorm users. Check the latest studies of Zelnorm.

On Jul, 10, 2026

41 people who take Melatonin and Zelnorm together, and have interactions are studied.

Melatonin and Zelnorm drug interactions.

What are the common drug interactions of Melatonin and Zelnorm, by gender? *:

female:

Abdominal pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Weight decreased
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Hepatic enzyme increased
Impaired gastric emptying
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)

male:

n/a

What are the common drug interactions of Melatonin and Zelnorm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chest discomfort
Chronic kidney disease
Malaise (a feeling of general discomfort or uneasiness)
Piloerection (goose bumps)
Weight decreased
Weight increased

50-59:

n/a

60+:

Abdominal pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Palpitations (feelings or sensations that your heart is pounding or racing)
Constipation
Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Abdominal discomfort
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 31 people, 75.61%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 27 people, 65.85%
High Blood Pressure: 14 people, 34.15%
Sleep Disorder: 5 people, 12.20%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 12.20%
Drowsiness: 5 people, 12.20%
Hypersensitivity: 4 people, 9.76%
Constipation: 4 people, 9.76%
Circadian Rhythm Sleep Disorder (family of sleep disorders affecting, among other things, the timing of sleep): 4 people, 9.76%
Sleep Apnea Syndrome: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

Do you take Melatonin and Zelnorm?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously