Mellaril and Cogentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mellaril (thioridazine hydrochloride) and Cogentin (benztropine mesylate). Common drug interactions include depressed level of consciousness among females and aggression among males.

The phase IV clinical study analyzes what interactions people have when they take Mellaril and Cogentin. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Mellaril?

Mellaril has active ingredients of thioridazine hydrochloride. eHealthMe is studying from 1,516 Mellaril users. Check the latest studies of Mellaril.

What is Cogentin?

Cogentin has active ingredients of benztropine mesylate. It is often used in tardive dyskinesia. eHealthMe is studying from 7,692 Cogentin users. Check the latest studies of Cogentin.

On Jul, 06, 2026

77 people who take Mellaril and Cogentin together, and have interactions are studied.

Mellaril and Cogentin drug interactions.

What are the common drug interactions of Mellaril and Cogentin, by gender? *:

female:

Depressed level of consciousness
Depression
Drug abuser
Dysarthria (speech disorder)
Dysuria (painful or difficult urination)
Galactorrhoea (secretion of breast milk in men)
Hypertension (high blood pressure)
Lymphadenopathy (disease or enlargement of lymph nodes)
Migraine (headache)
Mydriasis (a dilation of the pupil)

male:

Aggression
Agitation (state of anxiety or nervous excitement)
Gait abnormal
Glycosuria (excretion of glucose into the urine)
Haematemesis (vomiting of blood)
Hyperglycaemia (high blood sugar)
Type 2 diabetes mellitus
Acute circulatory failure (shock)
Alanine aminotransferase increased
Arrhythmia (irregular heartbeat)

What are the common drug interactions of Mellaril and Cogentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Sedation
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Dry mouth
Overdose
Stupor (lack of critical cognitive function and level of consciousness)
Catatonia (unresponsive to external stimuli)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Agitation (state of anxiety or nervous excitement)
Anger
Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)

20-29:

Aggression
Agitation (state of anxiety or nervous excitement)
Psychotic disorder
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Adjustment disorder
Adverse drug reaction
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatine phosphokinase increased

30-39:

Pain
Asthenia (weakness)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Logorrhoea (excessive, uncontrollable, or incoherent talkativeness)
Multiple drug overdose
Pyrexia (fever)
Thirst
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Heart rate increased
Hyperhidrosis (abnormally increased sweating)

40-49:

Accidental exposure
Blood pressure fluctuation
Body temperature increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Drug toxicity
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Electrolyte imbalance
Hyperglycaemia (high blood sugar)
Incontinence (lack of moderation or self-control)

50-59:

Delusion (a false belief or opinion)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Electrocardiogram qt prolonged
Electrocardiogram t wave inversion
Nightmare (unpleasant dream)
Type 1 diabetes mellitus
Type 2 diabetes mellitus
Vision blurred

60+:

Drug hypersensitivity
Furuncle (exc genital) (infection of the hair follicle including genital area)
Blood glucose increased
Carotid artery stenosis (narrowing of carotid artery)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Device related infection
Diarrhoea
Dizziness

What are the existing conditions these people have? *

Pain: 14 people, 18.18%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 6.49%
Bipolar Disorder (mood disorder): 5 people, 6.49%
Sleep Disorder: 4 people, 5.19%

* Approximation only. Some reports may have incomplete information.

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