Mellaril and Phenergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mellaril (thioridazine hydrochloride) and Phenergan (promethazine hydrochloride). Common drug interactions include radiculitis lumbosacral among females and schizophrenia among males.

The phase IV clinical study analyzes what interactions people have when they take Mellaril and Phenergan. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Mellaril?

Mellaril has active ingredients of thioridazine hydrochloride. eHealthMe is studying from 1,516 Mellaril users. Check the latest studies of Mellaril.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

On Aug, 08, 2026

19 people who take Mellaril and Phenergan together, and have interactions are studied.

Mellaril and Phenergan drug interactions.

What are the common drug interactions of Mellaril and Phenergan, by gender? *:

female:

Radiculitis lumbosacral (inflammation of nerve root at labosacral vertebrea)
Rectal haemorrhage (bleeding from anus)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Road traffic accident
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Snoring
Somnolence (a state of near-sleep, a strong desire for sleep)
Spinal osteoarthritis (joint cartilage loss in spine)
Suicidal ideation

male:

Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Abdominal distension
Confusional state
Diarrhoea
Drug ineffective
Dry mouth
Dyspnoea (difficult or laboured respiration)
Eating disorder
Eye irritation
Hallucination (an experience involving the perception of something not present)

What are the common drug interactions of Mellaril and Phenergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nervousness
Parent-child problem
Road traffic accident
Thinking abnormal
Unevaluable reaction
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Drug dependence
Anger
Exacerbation of anxiety (increase in the severity of anxiety)

40-49:

n/a

50-59:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Conjunctival abrasion (injury to outer surface of eye)
Dizziness
Exostosis (formation of new bone on the surface of a bone)
Furuncle (infection of the hair follicle)
Melaena (the passage of black, tarry stools)
Neck pain
Neuropathy peripheral (surface nerve damage)
Otitis externa (external ear infection)
Otitis media (inflammation of the middle ear)

60+:

Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Anxiety
Idiopathic thrombocytopenic purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting)
Ill-defined disorder
Leukocytosis (increased white blood cells)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Pain in extremity
Panic attack
Paraproteinaemia (normal or abnormal plasma protein appearing in large quantities)
Psychomotor hyperactivity (feelings of extreme restlessness)

What are the existing conditions these people have? *

Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 21.05%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 21.05%
Stress And Anxiety: 3 people, 15.79%
Pain: 3 people, 15.79%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 10.53%
Gastric Ulcer (stomach ulcer): 2 people, 10.53%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.53%
Depression: 2 people, 10.53%
Panic Disorder: 2 people, 10.53%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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