Melphalan and Hydrocortisone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Melphalan (melphalan) and Hydrocortisone (hydrocortisone). Common drug interactions include infusion related reaction among females and lung infiltration among males.

The phase IV clinical study analyzes what interactions people have when they take Melphalan and Hydrocortisone. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Melphalan?

Melphalan has active ingredients of melphalan. eHealthMe is studying from 20,052 Melphalan users. Check the latest studies of Melphalan.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,425 Hydrocortisone users. Check the latest studies of Hydrocortisone.

On Jul, 25, 2026

75 people who take Melphalan and Hydrocortisone together, and have interactions are studied.

Melphalan and Hydrocortisone drug interactions.

What are the common drug interactions of Melphalan and Hydrocortisone, by gender? *:

female:

Infusion related reaction
Lung disorder (lung disease)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Contrast media allergy (reaction associated with the use of intravenous contrast material during radiology)
Periorbital oedema (swelling around the eyes)
Abdominal distension
Acute respiratory distress syndrome
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Dyspnoea (difficult or laboured respiration)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

male:

Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Pruritus (severe itching of the skin)
Hypoxia (low oxygen in tissues)
Mucosal inflammation (infection of mucous membrane)
Pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Bacterial toxaemia (blood contains bacterial toxins)
Lung disorder (lung disease)
Neuropathy peripheral (surface nerve damage)

What are the common drug interactions of Melphalan and Hydrocortisone, by age (0-1 to 60+)? *:

0-1:

Cerebral vasoconstriction (constriction of brain blood vessels)
Hypertension (high blood pressure)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Oesophageal squamous cell carcinoma (cancer that begins in flat cells lining the oesophagus)
Contrast media allergy (reaction associated with the use of intravenous contrast material during radiology)
Mucosal inflammation (infection of mucous membrane)
Pain
Rectal haemorrhage (bleeding from anus)
Venoocclusive liver disease (small veins in the liver are obstructed)
Abdominal distension

2-9:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Drug ineffective
Engraftment syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Periorbital oedema (swelling around the eyes)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)

10-19:

Bacteraemia (presence of bacteria in the blood)
Viraemia (presence of a virus in the blood stream)
Blood lactate dehydrogenase increased
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hypertension (high blood pressure)
Lung disorder (lung disease)
Oesophagitis (inflammation of oesophagus)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Retinopathy (acute damage to the retina of the eye)

20-29:

Oesophagitis (inflammation of oesophagus)

30-39:

n/a

40-49:

Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Engraftment syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation)
Febrile neutropenia (fever with reduced white blood cells)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cystitis viral (inflammation of the wall of the bladder by virus)
Human herpesvirus 6 infection
Rash
Septic shock (shock due to blood infection)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)

50-59:

Chills (felling of cold)
Hypotension (abnormally low blood pressure)
Infusion related reaction
Pneumonia
Pyrexia (fever)
Acute respiratory distress syndrome
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Mucosal inflammation (infection of mucous membrane)
Nausea (feeling of having an urge to vomit)

60+:

Arthralgia (joint pain)
Hypoxia (low oxygen in tissues)
Prostatic specific antigen increased
Somnolence (a state of near-sleep, a strong desire for sleep)
Abscess neck (neck abscesses)
Anaemia of chronic disease
Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic dilatation
Arrhythmia (irregular heartbeat)

What are the existing conditions these people have? *

Bone Marrow Conditioning Regimen: 22 people, 29.33%
Peripheral T-Cell Lymphoma Unspecified Stage Iv (peripheral t-cell cancer unspecified stage iv): 15 people, 20.00%
Multiple Myeloma (cancer of the plasma cells): 12 people, 16.00%
Retinoblastoma (tumour of retina): 7 people, 9.33%
Hypotension (abnormally low blood pressure): 7 people, 9.33%
Fever: 7 people, 9.33%
Disease Progression: 6 people, 8.00%
Burkitt's Lymphoma (cancer of the lymphatic system): 5 people, 6.67%
Burkitt Lymphoma (cancer of the lymphatic system): 5 people, 6.67%
Mucosal Inflammation (infection of mucous membrane): 4 people, 5.33%

* Approximation only. Some reports may have incomplete information.

Do you take Melphalan and Hydrocortisone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously