Memantine and Codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Memantine (memantine) and Codeine (codeine sulfate). Common drug interactions include weight increased among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Memantine and Codeine. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Memantine?

Memantine has active ingredients of memantine. It is often used in alzheimer's disease. eHealthMe is studying from 10,266 Memantine users. Check the latest studies of Memantine.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

On Jul, 14, 2026

73 people who take Memantine and Codeine together, and have interactions are studied.

Memantine and Codeine drug interactions.

What are the common drug interactions of Memantine and Codeine, by gender? *:

female:

Weight increased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Thrombocytopenic purpura (a bleeding disorder in which the immune system destroys platelets)
Suicidal ideation
Drug hypersensitivity
Fall
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Rectal haemorrhage (bleeding from anus)
Vomiting

male:

Death
Pneumonia
Unresponsive to stimuli
Drug ineffective
Oxygen saturation decreased
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
Pleural effusion (water on the lungs)
Somnolence (a state of near-sleep, a strong desire for sleep)
Chronic kidney disease
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)

What are the common drug interactions of Memantine and Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Weight increased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Thrombocytopenic purpura (a bleeding disorder in which the immune system destroys platelets)
Suicidal ideation

20-29:

n/a

30-39:

n/a

40-49:

Death
Pneumonia

50-59:

Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dyspnoea (difficult or laboured respiration)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Pulse pressure decreased
Unresponsive to stimuli
Oxygen saturation decreased

60+:

Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Rectal haemorrhage (bleeding from anus)
Renal failure (kidney dysfunction)
Adverse drug reaction
Bradycardia (abnormally slow heart action)
Cardiomyopathy (weakening of the heart muscle)
Cystitis (inflammation of the wall of the bladder)
Death
Drug hypersensitivity
Electrocardiogram qt prolonged

What are the existing conditions these people have? *

Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 49 people, 67.12%

* Approximation only. Some reports may have incomplete information.

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