Merrem and Compazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Merrem (meropenem) and Compazine (prochlorperazine maleate). Common drug interactions include hypertension among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Merrem and Compazine. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Merrem?

Merrem has active ingredients of meropenem. eHealthMe is studying from 996 Merrem users. Check the latest studies of Merrem.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in nausea and vomiting. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

28 people who take Merrem and Compazine together, and have interactions are studied.

What are the common drug interactions of Merrem and Compazine, by gender? *:

female:

Hypertension (high blood pressure)
Hypokalaemia (low potassium)
Hypoxia (low oxygen in tissues)
Insomnia (sleeplessness)
Ketosis (a state of elevated levels of ketone bodies in the body)
Myalgia (muscle pain)
Neoplasm progression (growth of tumour)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Osteonecrosis (death of bone)

male:

Headache (pain in head)
Chest pain
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Night sweats (sweating in night)
Productive cough
Pruritus (severe itching of the skin)
Pseudomonas test positive
Secretion discharge
Sputum discoloured

What are the common drug interactions of Merrem and Compazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Acute hepatic failure
Arthralgia (joint pain)
Aspartate aminotransferase increased
Decreased appetite
Encephalopathy (functioning of the brain is affected by some agent or condition)
Epistaxis (bleed from the nose)
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypercalcaemia (elevated calcium (ca+) level in the blood)

30-39:

Asthenia (weakness)
Chest discomfort
Chest pain
Cough
Decreased appetite
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)

40-49:

Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Hypovolaemia (a decreased volume of circulating blood in the body)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Pneumonia
Pulmonary oedema (fluid accumulation in the lungs)
Renal failure acute (rapid kidney dysfunction)
Septic shock (shock due to blood infection)

50-59:

Abdominal pain
Angioimmunoblastic t-cell lymphoma stage iv (mature t-cell cancer of the blood or lymph vessel-stage iv)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dysuria (painful or difficult urination)
Ear pain
Failure to thrive (inadequate weight gain and physical growth in children)
Hyperchloraemia (an excess of chlorides in the blood)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Ketosis (a state of elevated levels of ketone bodies in the body)

60+:

Haemoglobin decreased
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Electrocardiogram qt prolonged
Febrile neutropenia (fever with reduced white blood cells)
Gait disturbance
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hypotension (abnormally low blood pressure)
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Memory impairment

What are the existing conditions these people have? *

Pain: 20 people, 71.43%
Stress And Anxiety: 14 people, 50.00%
Nausea (feeling of having an urge to vomit): 14 people, 50.00%
Sepsis (a severe blood infection that can lead to organ failure and death): 10 people, 35.71%
Fungal Infection: 10 people, 35.71%
Constipation: 9 people, 32.14%
Fever: 6 people, 21.43%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 6 people, 21.43%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 5 people, 17.86%
Muscle Spasms (muscle contraction): 5 people, 17.86%

* Approximation only. Some reports may have incomplete information.

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