Mesalamine and Bentyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mesalamine (mesalamine) and Bentyl (dicyclomine hydrochloride). Common drug interactions include hypotension among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Mesalamine and Bentyl. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Mesalamine?

Mesalamine has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 28,053 Mesalamine users. Check the latest studies of Mesalamine.

What is Bentyl?

Bentyl has active ingredients of dicyclomine hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 10,754 Bentyl users. Check the latest studies of Bentyl.

On Jul, 30, 2026

77 people who take Mesalamine and Bentyl together, and have interactions are studied.

Mesalamine and Bentyl drug interactions.

What are the common drug interactions of Mesalamine and Bentyl, by gender? *:

female:

Hypotension (abnormally low blood pressure)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Immunodeficiency
Impaired healing
Influenza
Injection site bruising
Injection site pain
Leukocytosis (increased white blood cells)
Liver abscess (pus in liver)
Lung infection

male:

Renal failure (kidney dysfunction)
Sinus disorder (disease of sinus)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Bone loss
Catatonia (unresponsive to external stimuli)
Cholecystitis chronic (long lasting infection of gallbladder)
Death

What are the common drug interactions of Mesalamine and Bentyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hepatosplenic t-cell lymphoma (neoplasm comprising medium-sized cytotoxic t-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow)
Renal failure (kidney dysfunction)
Sinus disorder (disease of sinus)
Collapse of lung (functional breakdown of lung)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Pyelonephritis (inflammation of kidney caused by bacteria)
Cholecystitis chronic (long lasting infection of gallbladder)
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Gallbladder injury
Pain

20-29:

Diarrhoea
Anaemia (lack of blood)
Fatigue (feeling of tiredness)
Immunodeficiency
Vomiting
Abdominal discomfort
Abdominal pain lower
Asthenia (weakness)
Back pain
Bladder disorder

30-39:

Pain
Arthralgia (joint pain)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Diarrhoea
Emotional distress
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Fatigue (feeling of tiredness)
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Influenza
Meningitis viral (viral inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)

40-49:

Diarrhoea haemorrhagic (bloody diarrhoea)
Frequent bowel movements
Insomnia (sleeplessness)
Retching (strong involuntary effort to vomit)
Vomiting
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Injection site bruising
Injection site haemorrhage (bleeding from injection site)

50-59:

Cardiac failure congestive
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Colon cancer
Diarrhoea
Drug intolerance (drug sensitivity)
Duodenitis (inflammation of the duodenum)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Focal nodular hyperplasia (tumour of the liver)
Gastrointestinal disorder (functional problems of gastrointestinal tract)

60+:

Epistaxis (bleed from the nose)
Hypoaesthesia (reduced sense of touch or sensation)
Limb discomfort (discomfort in leg)
Loss of consciousness
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Night sweats (sweating in night)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Restless legs syndrome (a powerful urge to move your legs)
Upper respiratory tract infection

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 34 people, 44.16%
Pain: 9 people, 11.69%
Inflammatory Bowel Disease: 9 people, 11.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 9.09%
Nausea (feeling of having an urge to vomit): 5 people, 6.49%
Diabetes: 5 people, 6.49%
Indigestion: 4 people, 5.19%

* Approximation only. Some reports may have incomplete information.

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