Mesna and Valsartan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mesna (mesna) and Valsartan (valsartan). Common drug interactions include polyarthritis among females and hyperkalaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Mesna and Valsartan. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Mesna?

Mesna has active ingredients of mesna. eHealthMe is studying from 9,647 Mesna users. Check the latest studies of Mesna.

What is Valsartan?

Valsartan has active ingredients of valsartan. It is often used in high blood pressure. eHealthMe is studying from 63,805 Valsartan users. Check the latest studies of Valsartan.

On Jul, 21, 2026

72 people who take Mesna and Valsartan together, and have interactions are studied.

What are the common drug interactions of Mesna and Valsartan, by gender? *:

female:

Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Fatigue (feeling of tiredness)
Back pain
Constipation
Leukopenia (less number of white blood cells in blood)
Oropharyngeal pain
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Rash
Congestive cardiomyopathy (weakening of heart muscle)
Ejection fraction decreased (systolic heart failure)

male:

Hyperkalaemia (damage to or disease of the kidney)
Headache (pain in head)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
White blood cell count decreased
Agitation (state of anxiety or nervous excitement)
Confusional state
Gastrointestinal infection (infection of stomach and intestine)
Inappropriate antidiuretic hormone secretion
Infection
Klebsiella infection

What are the common drug interactions of Mesna and Valsartan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood creatine phosphokinase increased
Gastroenteritis (inflammation of stomach and intestine)
Hyperlipidaemia (presence of excess lipids in the blood)
Hyperuricaemia (level of uric acid in the blood that is abnormally high)
Iron deficiency anaemia
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Nasopharyngitis (inflammation of the nasopharynx)
Osteonecrosis (death of bone)
Otitis externa (external ear infection)
Purpura (purplish discoloration of the skin)

30-39:

Drug intolerance (drug sensitivity)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Hyperkalaemia (damage to or disease of the kidney)
Therapeutic response decreased (less preventive response)
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Malignant neoplasm progression (cancer tumour came back)

40-49:

n/a

50-59:

Congestive cardiomyopathy (weakening of heart muscle)
Ejection fraction decreased (systolic heart failure)
Respiratory failure (inadequate gas exchange by the respiratory system)
Cough
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
Rigors (an episode of shaking or exaggerated shivering)

60+:

Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Fatigue (feeling of tiredness)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
White blood cell count decreased
Chondrocalcinosis (crystal deposition disease)
Klebsiella infection
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pyrexia (fever)
Bone marrow toxicity (decrease in cells responsible for providing immunity, carrying oxygen, and those responsible for normal blood clotting)
Monoplegia (a paralysis of a single limb)

What are the existing conditions these people have? *

Allergies: 24 people, 33.33%
Mantle Cell Lymphoma Stage Iv (cancer of lymphocytes, a type of white blood cell, spreads to other part of body): 22 people, 30.56%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 17 people, 23.61%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 15 people, 20.83%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 14 people, 19.44%
Depression: 11 people, 15.28%
Renal Vein Thrombosis (blood clot in renal vein): 10 people, 13.89%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 8 people, 11.11%
Osteoporosis (bones weak and more likely to break): 6 people, 8.33%
Nausea (feeling of having an urge to vomit): 6 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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