Methadone hydrochloride and Keytruda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methadone hydrochloride (methadone hydrochloride) and Keytruda (pembrolizumab). Common drug interactions include nausea among females and renal tubular acidosis among males.

The phase IV clinical study analyzes what interactions people have when they take Methadone hydrochloride and Keytruda. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Methadone hydrochloride?

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 8,598 Methadone hydrochloride users. Check the latest studies of Methadone hydrochloride.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

60 people who take Methadone hydrochloride and Keytruda together, and have interactions are studied.

Methadone hydrochloride and Keytruda drug interactions.

What are the common drug interactions of Methadone Hydrochloride and Keytruda, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Diarrhoea
Vomiting
Headache (pain in head)
Fatigue (feeling of tiredness)
Abdominal pain
Anxiety
Back pain
Blood glucose increased
Blood thyroid stimulating hormone increased

male:

Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Decreased appetite
Cerebral hypoperfusion (a condition in which the brain doesn't get enough blood)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Erysipelas (bacterial skin infection)
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)
Hypertension (high blood pressure)
Liver disorder (liver diseases)

What are the common drug interactions of Methadone Hydrochloride and Keytruda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Adverse event
Death
Blood pressure increased
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Fatigue (feeling of tiredness)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Tumour pain

30-39:

Blood creatinine increased
Prerenal failure

40-49:

Fatigue (feeling of tiredness)
Abdominal pain
Anxiety
Back pain
Blood glucose increased
Blood thyroid stimulating hormone increased
Body temperature increased
Chest pain
Constipation
Diarrhoea

50-59:

Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal pain
Decreased appetite
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Peripheral coldness
Pyrexia (fever)
Rash
Dehydration (dryness resulting from the removal of water)

60+:

Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Antineutrophil cytoplasmic antibody positive
Colitis (inflammation of colon)
Diarrhoea
Metastatic neoplasm (spreadable cancer tumour)
Nephropathy toxic (damage to kidney due to toxins)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Acute myocardial infarction (acute heart attack)
Cardiac failure

What are the existing conditions these people have? *

Pneumonia: 15 people, 25.00%
Non-Small Cell Lung Cancer Stage 0: 14 people, 23.33%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 14 people, 23.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 11 people, 18.33%
Constipation: 7 people, 11.67%
Lung Squamous Cell Carcinoma Stage Iv (the lung cancer has spread to the other lung, and/or to lymph nodes, fluid around the lungs or heart, and/or other places in the body, such as the brain, liver, adrenal glands, kidneys, or bones): 6 people, 10.00%
Lung Cancer - Non-Small Cell (lung cancer): 6 people, 10.00%
Hiv Infection: 6 people, 10.00%
Endometrial Cancer: 6 people, 10.00%
Hypoaesthesia (reduced sense of touch or sensation): 5 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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